所有图片(1)
About This Item
经验公式（希尔记法）:
C10H16FNO4
CAS号:
分子量:
233.24
MDL编号:
UNSPSC代码:
12352005
PubChem化学物质编号:
NACRES:
NA.22
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方案
97%
表单
solid
旋光性
[α]22/D −71.0±5°, c = 1 in chloroform
mp
157-161 °C (D)
官能团
carboxylic acid
fluoro
SMILES字符串
CC(C)(C)OC(=O)N1C[C@@H](F)C[C@H]1C(O)=O
InChI
1S/C10H16FNO4/c1-10(2,3)16-9(15)12-5-6(11)4-7(12)8(13)14/h6-7H,4-5H2,1-3H3,(H,13,14)/t6-,7-/m0/s1
InChI key
YGWZXQOYEBWUTH-BQBZGAKWSA-N
应用
N-Boc-cis-4-fluoro-L-proline can be used as a substrate in the preparation of:
- α4β2 Receptor ligands bearing pyrrolidine nucleus.
- β-Amino pyrrolidine-2-carbonitrile derivatives as possible dipeptidyl peptidase IV (DPP4) inhibitors.
警示用语：
Warning
危险声明
危险分类
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
法规信息
新产品
Design, synthesis and biological evaluation of 4-fluoropyrrolidine-2-carbonitrile and octahydrocyclopenta [b] pyrrole-2-carbonitrile derivatives as dipeptidyl peptidase IV inhibitors
Ji X, et al.
European Journal of Medicinal Chemistry, 86(6), 242-256 (2014)
Synthesis and Pharmacological Evaluation of α4β2 Nicotinic Ligands with a 3-Fluoropyrrolidine Nucleus
Tamborini L, et al.
ChemMedChem, 10(6), 1071-1078 (2015)
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