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Merck
CN

681059

Sigma-Aldrich

2-甲基-6-硝基苯甲酸酐

97%

别名:

MNBA

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About This Item

经验公式(希尔记法):
C16H12N2O7
分子量:
344.28
MDL编号:
UNSPSC代码:
12352108
PubChem化学物质编号:
NACRES:
NA.22

质量水平

方案

97%

表单

solid

mp

173-177 °C

官能团

anhydride
ester
nitro

SMILES字符串

Cc1cccc(c1C(=O)OC(=O)c2c(C)cccc2[N+]([O-])=O)[N+]([O-])=O

InChI

1S/C16H12N2O7/c1-9-5-3-7-11(17(21)22)13(9)15(19)25-16(20)14-10(2)6-4-8-12(14)18(23)24/h3-8H,1-2H3

InChI key

YEKPNMQQSPHKBP-UHFFFAOYSA-N

一般描述

2-甲基-6-硝基苯甲酸酐可用作酰胺、内酯、酯和肽合成中的偶联促进剂。

应用

2-甲基-6-硝基苯甲酸酐可用于:
  • 作为多功能的内酯化试剂用于制备各种大环内酯天然产物和内酯。
  • 作为反应促进剂采用相应的胺和羧酸合成羧酰胺衍生物。
  • GRP78 抑制剂 prunustatin A、抗真菌化合物 (3R,16E,20E,23R)-(−)-eushearilide 和防肥胖药四氢利泼斯汀的全合成。

象形图

Exclamation mark

警示用语:

Warning

危险声明

危险分类

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

靶器官

Respiratory system

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves


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分析证书(COA)

Lot/Batch Number

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访问文档库

2-Methyl-6-nitrobenzoic anhydride
Encyclopedia of Reagents for Organic Synthesis, Second Edition (2009)
Dahye Kim et al.
Molecules (Basel, Switzerland), 26(4) (2021-02-12)
Steroid 5-α reductase (5AR) is responsible for the reduction of steroids to 5-α reduced metabolites, such as the reduction of testosterone to 5-α dihydrotestosterone (DHT). A new adverse outcome pathway (AOP) for 5AR inhibition to reduce female reproduction in fish
Takayuki Tonoi et al.
ACS omega, 6(5), 3571-3577 (2021-02-16)
A depsipeptidic analogue of FE399 was efficiently synthesized mainly through macrolactamization using 2-methyl-6-nitrobenzoic anhydride (MNBA), and a detailed investigation of the desired 16-membered macrolactam core of FE399 was performed. It was determined that the combination of MNBA and a catalytic
Ryohei Hirano et al.
Journal of mass spectrometry : JMS, 53(8), 665-674 (2018-05-17)
CYP3A phenotyping provides a means for personalized drug therapy. We focused our attention on the plasma 6β-hydroxycortisol (6β-OHF) to cortisol ratio as an index for CYP3A phenotyping. In the present study, we developed a sensitive and reliable method for the
A novel and efficient macrolactonization of ω-hydroxycarboxylic acids using 2-methyl-6-nitrobenzoic anhydride (MNBA)
Shiina S, et al.
Tetrahedron Letters, 43(42), 7535-7539 (2002)

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