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Merck
CN
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文件

677418

Sigma-Aldrich

羟基磷灰石

nanopowder, <200 nm particle size (BET), ≥97%, synthetic

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别名:
磷酸钙 三元, 三碱基磷酸钙, 氢氧磷灰石, 磷酸羟胺, 羟基磷酸钙
线性分子式:
[Ca5(OH)(PO4)3]x
CAS号:
12167-74-7
分子量:
502.31
EC 号:
235-330-6
MDL编号:
MFCD00010904
UNSPSC代码:
12352302
PubChem化学物质编号:
24885371
NACRES:
NA.23

质量水平

100

检测方案

≥97%

形式

nanopowder
solid

表面积

>9.4 m2/g

粒径

<200 nm (BET)

mp

1100 °C (lit.)

SMILES字符串

[Ca++].[Ca++].[Ca++].[Ca++].O[Ca+].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O

InChI

1S/5Ca.3H3O4P.H2O/c;;;;;3*1-5(2,3)4;/h;;;;;3*(H3,1,2,3,4);1H2/q5*+2;;;;/p-10

InChI key

XYJRXVWERLGGKC-UHFFFAOYSA-D

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相关类别

一般描述

羟基磷灰石（HA）属于钙磷灰石家族， 在结构和化学成分上与天然骨相似。它可以 通过化学沉淀法、水热法、静电纺丝法和 自传播燃烧法等多种方法制备。由于其生物活性和生物相容性， 它被广泛用作骨再生的植入材料、 药物载体和基因传递系统。

应用

纳米羟基磷灰石颗粒具有缓慢的原位生物降解、良好的骨导电性和骨诱导能力，可用于制备骨组织工程材料。

聚(4-苯乙烯磺酸钠)修饰的羟基磷灰石纳米颗粒可作为万古霉素的药物载体。羟基磷灰石纳米颗粒可控制支架植入体内后抗生素的释放。

多孔羟基磷灰石微球对重金属具有较高的吸附能力，可用于重金属污染水体的处理。

特点和优势

  • 生物活性和生物相容性
  • 机械强度好
  • 多孔结构
  • 骨传导和骨整合特性

法律信息

Engi-Mat公司产品。

WGK

WGK 1

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves

分析证书(COA)

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Furqan A Shah
Scientific reports, 10(1), 16662-16662 (2020-10-09)
Various compositional parameters are derived using intensity ratios and integral area ratios of different spectral peaks and bands in the Raman spectrum of bone. The [Formula: see text]1-, [Formula: see text]2-,[Formula: see text]3-, [Formula: see text]4 PO43-, and [Formula: see
Sang-Soo Kim et al.
Biomaterials, 27(8), 1399-1409 (2005-09-20)
Biodegradable polymer/bioceramic composite scaffolds can overcome the limitations of conventional ceramic bone substitutes such as brittleness and difficulty in shaping. However, conventional methods for fabricating polymer/bioceramic composite scaffolds often use organic solvents (e.g., the solvent casting and particulate leaching (SC/PL)
Michiko Sato et al.
Biomaterials, 27(11), 2358-2369 (2005-12-13)
In order to improve orthopedic implant performance, the objective of this in vitro study was to synthesize nanocrystalline hydroxyapatite (HA) powders to coat titanium. HA was synthesized through a wet chemical process. The precipitated powders were either sintered at 1100
Influence of temperature, ripening time and calcination on the morphology and crystallinity of hydroxyapatite nanoparticles.
Pang YX, et al.
J. Eur. Ceram. Soc., 23(10), 1697-1704 (2003)
Deepak Bushan Raina et al.
Acta orthopaedica, 91(2), 126-132 (2019-11-05)
Background and purpose - Targeted delivery of drugs is important to achieve efficient local concentrations and reduce systemic side effects. We hypothesized that locally implanted synthetic hydroxyapatite (HA) particles can act as a recruiting moiety for systemically administered drugs, leading
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