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Merck
CN

677019

Sigma-Aldrich

(S)-α,α-双 [3,5-双(三氟甲基)苯基]-2-吡咯烷甲醇三甲基硅醚

97%

别名:

(S)-α,α-[3,5-双(三氟甲基)苯基]脯氨醇三甲基硅醚, (S)-2-[(双(3,5-双(三氟甲基)苯基)三甲基甲硅氧基)甲基]吡咯烷, (S)-2-[(双(3,5-双(三氟甲基)苯基)三甲基硅烷氧基)甲基]吡咯烷

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About This Item

经验公式(希尔记法):
C24H23F12NOSi
分子量:
597.51
MDL编号:
UNSPSC代码:
12352005
PubChem化学物质编号:
NACRES:
NA.22

质量水平

检测方案

97%

mp

48-56 °C

SMILES字符串

C[Si](C)(C)OC([C@@H]1CCCN1)(c2cc(cc(c2)C(F)(F)F)C(F)(F)F)c3cc(cc(c3)C(F)(F)F)C(F)(F)F

InChI

1S/C24H23F12NOSi/c1-39(2,3)38-20(19-5-4-6-37-19,13-7-15(21(25,26)27)11-16(8-13)22(28,29)30)14-9-17(23(31,32)33)12-18(10-14)24(34,35)36/h7-12,19,37H,4-6H2,1-3H3/t19-/m0/s1

InChI key

MOHRGTBNEJKFMB-IBGZPJMESA-N

一般描述

(S)-α,α-双 [3,5-双(三氟甲基)苯基]-2-吡咯烷甲醇三甲基硅醚是一种二芳基脯氨醇硅醚有机催化剂。它能催化 C-C、C-N、C-O、C-S 和 C-Hal 等多种键形成反应,产率高,对映体控制水平优良。

象形图

Exclamation mark

警示用语:

Warning

危险声明

危险分类

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

靶器官

Respiratory system

WGK

WGK 3

闪点(°F)

>230.0 °F

闪点(°C)

> 110 °C

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves


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The diarylprolinol silyl ether system: a general organocatalyst.
Jensen KL, et al.
Accounts of Chemical Research, 45(2), 248-264 (2011)

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Professor Karl Anker Jørgensen and his group have developed ethers which serve as excellent chiral organocatalysts in the direct asymmetric α-functionalization of aldehydes.

Professor Geoffrey Coates and co-workers at Cornell University have reported the preparation and use of catalysts composed of an oxophilic Lewis acid and a cobalt tetracarbonyl anion for the ring expansive carbonylation of epoxides to b-lactones and b-lactones to succinic anhydrides.

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