检测方案
≥97.0% (GC)
旋光性
[α]/D -145±5°, c = 4.47 in chloroform
mp
39-44 °C
储存温度
2-8°C
SMILES字符串
CN[C@@H]1CCCC[C@H]1NC
InChI
1S/C8H18N2/c1-9-7-5-3-4-6-8(7)10-2/h7-10H,3-6H2,1-2H3/t7-,8-/m1/s1
InChI key
JRHPOFJADXHYBR-HTQZYQBOSA-N
一般描述
(R,R)-(-)-N,N′-Dimethyl-1,2-cyclohexanediamine is a N,N′-dimethylated derivative of enantiopure 1,2-diaminocyclohexane. It can be formed during the hydrolysis of (R3a,R7a)-1,3-(dimethyl)-2-phenyl-2,3,3a,4,5,6,7,7a-octahydro-1H-1,3,2-benzodiazaphosphole 2-oxide using HCl-methanol.
应用
(R,R)-(−)-N,N′-Dimethyl-1,2-cyclohexanediamine can be used:
- As a ligand in the preparation of 4H-benzo[f]imidazo[1,4]diazepin-6-one through multi-component Ullmann coupling reaction.
- In one of the key synthetic steps for the preparation of tricyclic γ-secretase modulators.
- To prepare chiral fluorous diamino-diol proligand, which is used in the synthesis of zirconium metal complexes applicable as catalysts in 1-hexene polymerization.
警示用语：
Danger
危险声明
危险分类
Acute Tox. 4 Oral - Eye Dam. 1 - Skin Corr. 1B
WGK
WGK 3
闪点(°F)
165.2 °F
闪点(°C)
74 °C
个人防护装备
Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter
Microwave-assisted synthesis of 4H-benzo [f] imidazo [1, 4] diazepin-6-ones via a post-Ugi copper-catalyzed intramolecular Ullmann coupling
Li Z, et al.
Tetrahedron Letters, 55(13), 2070-2074 (2014)
Chiral Fluorous Dialkoxy-Diamino Zirconium Complexes: Synthesis and Use imn Stereospecific Polymerization of 1-Hexene
Kirillov E, et al.
Chemistry?A European Journal , 13(3), 923-935 (2007)
Design and optimization of tricyclic gamma-secretase modulators
Shi J, et al.
Bioorganic & Medicinal Chemistry Letters, 26(5), 1498-1502 (2016)
An efficient method for the synthesis of N,N'-dimethyl-1, 2-diamines.
Tye H, et al.
Tetrahedron Letters, 43(1), 155-158 (2002)
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系技术服务部门