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检测方案
97%
形式
solid
mp
122-126 °C
SMILES字符串
OC(=O)C(Cl)Cl.CN1C(=O)[C@@H](Cc2ccccc2)NC1(C)C
InChI
1S/C13H18N2O.C2H2Cl2O2/c1-13(2)14-11(12(16)15(13)3)9-10-7-5-4-6-8-10;3-1(4)2(5)6/h4-8,11,14H,9H2,1-3H3;1H,(H,5,6)/t11-;/m1./s1
InChI key
YZRAPAXOLQHZSE-RFVHGSKJSA-N
应用
(5R)-(+)-2,2,3-Trimethyl-5-benzyl-4-imidazolidinone dichloroacetic acid is a Macmillan imidazolidinone organocatalyst that can be used in the enantioselective organocatalytic α-fluorination of aldehydes and cyclic ketones.
法律信息
适用美国专利6,369,243 和相关专利。仅供研究使用。
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
Enantioselective organocatalytic alpha-fluorination of aldehydes
Journal of the American Chemical Society, 127(24), 8826-8828 (2005)
Enantiomeric impurities in chiral catalysts, auxiliaries, and synthons used in enantioselective syntheses. Part 5
Chirality, 31(9), 688-699 (2019)
Journal of the American Chemical Society, 127(24), 8826-8828 (2005-06-16)
The first direct enantioselective catalytic alpha-fluorination of aldehydes has been accomplished. The use of enamine catalysis has provided a new organocatalytic strategy for the enantioselective fluorination of aldehydes to generate alpha-fluoro aldehydes, an important chiral synthon for medicinal agent synthesis.
Modern strategies in organic catalysis: the advent and development of iminium activation.
Aldrichimica Acta, 39(3), 79-87 (2006)
商品
Discover Professor David MacMillan's groundbreaking metal-free asymmetric catalysis using imidazolidinone-based organocatalysts for versatile transformations.
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