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653152

Sigma-Aldrich

4-巯基苯基乙酸

97%

别名:

2-（4-巯基苯基）乙酸, 4-巯基苯基乙酸, 对巯基苯乙酸, （4-巯基苯基）乙酸, （4-羧甲基）苯硫酚

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About This Item

线性分子式:
HSC6H4CH2CO2H
CAS号:
39161-84-7
分子量:
168.21
MDL编号:
MFCD00797617
UNSPSC代码:
12352100
PubChem化学物质编号:
24883931
NACRES:
NA.22

质量水平

100

方案

97%

表单

solid

mp

105-109 °C (lit.)

官能团

carboxylic acid

储存温度

2-8°C

SMILES字符串

OC(=O)Cc1ccc(S)cc1

InChI

1S/C8H8O2S/c9-8(10)5-6-1-3-7(11)4-2-6/h1-4,11H,5H2,(H,9,10)

InChI key

ORXSLDYRYTVAPC-UHFFFAOYSA-N

相关类别

一般描述

4-巯基苯基乙酸(MPAA)是一种硫醇添加剂，广泛应用于自然化学偶联（NCL）反应，用于肽片段的选择性高效偶联。

应用

4-巯基苯基乙酸用于通过序列自然化学连接由双（2-磺酰乙基）氨基肽制备小泛素修饰肽。
可用于：
  • 树脂制备肽-α噻吩基酯，以在化学连接过程中化学合成多肽。
  • 在一锅法中，采用天然化学连接和/或脱硫法去保护（乙酰胺基-甲基）半胱氨酸来制备多肽。
  • 钯通过天然化学连接法促进N-端半胱氨酸去保护，以制备合成挑战性蛋白。

象形图

CorrosionExclamation mark
GHS05,GHS07

警示用语：

Danger

危险声明

H315,H318,H335

危险分类

Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3

靶器官

Respiratory system

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
MKCX0024
MKCT0499
MKCS7237
MKCR1774
MKCQ8150

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