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Merck
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主要文件

653152

Sigma-Aldrich

4-巯基苯基乙酸

97%

别名:

2-(4-巯基苯基)乙酸, 4-巯基苯基乙酸, 对巯基苯乙酸, (4-巯基苯基)乙酸, (4-羧甲基)苯硫酚

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3 EA
CN¥4,994.89

CN¥4,994.89


国内现货,预计发货时间April 24, 2025详情


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3 EA
CN¥4,994.89

About This Item

线性分子式:
HSC6H4CH2CO2H
CAS号:
分子量:
168.21
MDL编号:
UNSPSC代码:
12352100
PubChem化学物质编号:
NACRES:
NA.22

CN¥4,994.89


国内现货,预计发货时间April 24, 2025详情


获取大包装报价

质量水平

方案

97%

表单

solid

mp

105-109 °C (lit.)

官能团

carboxylic acid

储存温度

2-8°C

SMILES字符串

OC(=O)Cc1ccc(S)cc1

InChI

1S/C8H8O2S/c9-8(10)5-6-1-3-7(11)4-2-6/h1-4,11H,5H2,(H,9,10)

InChI key

ORXSLDYRYTVAPC-UHFFFAOYSA-N

比较类似商品

查看完整比较结果

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1 of 4

此商品
ALD00062ALD00192ALD00044
reaction suitability

reaction type: click chemistry

reaction suitability

reaction type: click chemistry

reaction suitability

reaction type: click chemistry

reaction suitability

reaction type: click chemistry

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

form

liquid

form

solid

form

solid

form

solid

refractive index

n/D 1.476

refractive index

-

refractive index

-

refractive index

-

density

1.421 at 25 °C

density

-

density

-

density

-

一般描述

4-巯基苯基乙酸(MPAA)是一种硫醇添加剂,广泛应用于自然化学偶联(NCL)反应,用于肽片段的选择性高效偶联。[1]

应用

4-巯基苯基乙酸用于通过序列自然化学连接由双(2-磺酰乙基)氨基肽制备小泛素修饰肽。[2]
可用于:
  • 树脂制备肽-α噻吩基酯,以在化学连接过程中化学合成多肽。[3]
  • 在一锅法中,采用天然化学连接和/或脱硫法去保护(乙酰胺基-甲基)半胱氨酸来制备多肽。[4]
  • 钯通过天然化学连接法促进N-端半胱氨酸去保护,以制备合成挑战性蛋白。[5]

象形图

CorrosionExclamation mark

警示用语:

Danger

危险声明

危险分类

Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3

靶器官

Respiratory system

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves


  • 历史批次信息供参考:

    分析证书(COA)

    Lot/Batch Number

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    Sunithi Gunasekera et al.
    Frontiers in microbiology, 11, 168-168 (2020-03-11)
    Can antimicrobial activity and peptide stability of alpha-helical peptides be increased by making them into dimers and macrocycles? Here, we explore that concept by using KR-12 as the starting point for peptide engineering. KR-12 has previously been determined as the
    Direct on-resin synthesis of peptide-αthiophenylesters for use in native chemical ligation
    Bang D, et al.
    Organic Letters, 8(6), 1049-1052 (2006)
    Jailson Brito Querido et al.
    Science (New York, N.Y.), 369(6508), 1220-1227 (2020-09-05)
    A key step in translational initiation is the recruitment of the 43S preinitiation complex by the cap-binding complex [eukaryotic initiation factor 4F (eIF4F)] at the 5' end of messenger RNA (mRNA) to form the 48S initiation complex (i.e., the 48S).
    Daniel J Capon et al.
    Proceedings of the Japan Academy. Series B, Physical and biological sciences, 87(9), 603-616 (2011-11-15)
    There is a significant need for antibodies that can bind targets with greater affinity. Here we describe a novel strategy employing chemical semisynthesis to produce symmetroadhesins: antibody-like molecules having nonprotein hinge regions that are more flexible and extendible and are
    Efficient palladium-assisted one-pot deprotection of (acetamidomethyl) cysteine following native chemical ligation and/or desulfurization to expedite chemical protein synthesis
    Maity SK, et al.
    Angewandte Chemie (International Edition in English), 55(28), 8108-8112 (2016)

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