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Merck
CN

64046

Sigma-Aldrich

2,3-二巯基-1-丙醇

≥98% (iodometric)

别名:

BAL, DMP, 二巯丙醇, 二硫代甘油, 英国抗路易气剂

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About This Item

线性分子式:
HOCH2CH(SH)CH2SH
CAS号:
分子量:
124.23
Beilstein:
1732058
EC 号:
MDL编号:
UNSPSC代码:
12352100
PubChem化学物质编号:
NACRES:
NA.22

质量水平

方案

≥98% (iodometric)

折射率

n20/D 1.572-1.574
n20/D 1.573 (lit.)

沸点

120 °C/15 mmHg (lit.)

密度

1.239 g/mL at 25 °C (lit.)

官能团

hydroxyl
thiol

储存温度

2-8°C

SMILES字符串

OCC(S)CS

InChI

1S/C3H8OS2/c4-1-3(6)2-5/h3-6H,1-2H2

InChI key

WQABCVAJNWAXTE-UHFFFAOYSA-N

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相关类别

一般描述

二巯丙醇用作螯合剂,可与某些重金属形成稳定的络合物,如砷、汞和铅。

应用

2,3-二巯基-1-丙醇已用于合成新型(2-取代苯基-1,3-二硫杂环戊烷-4-基)甲醇(PDTM)衍生物,它们是有效的酪氨酸酶抑制剂。 由于它能够抑制HIV-1 tat活性,因此,它被认为可用于开发抗艾滋病新药。

象形图

Skull and crossbones

警示用语:

Danger

危险分类

Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

靶器官

Respiratory system

储存分类代码

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

闪点(°F)

233.6 °F - closed cup

闪点(°C)

112 °C - closed cup

个人防护装备

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Bjorklund G, et al.
Archives of Toxicology, 91(12), 3787-3797 (2017)
S Kubota et al.
AIDS research and human retroviruses, 6(7), 919-927 (1990-07-01)
We have examined the effect of 2,3 dimercapto-1-propanol (DMP), which is known as an anti-heavy metal-poisoning drug, against human immunodeficiency virus type 1 (HIV-1). We demonstrate that DMP inhibited transactivation directed by tat protein, which is a metal containing transcriptional
Raoul Herbrecht et al.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 60(5), 713-720 (2014-11-22)
Strict definition of invasive aspergillosis (IA) cases is required to allow precise conclusions about the efficacy of antifungal therapy. The Global Comparative Aspergillus Study (GCAS) compared voriconazole to amphotericin B (AmB) deoxycholate for the primary therapy of IA. Because predefined
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Lymphocytic airway inflammation is a major risk factor for chronic lung allograft dysfunction, for which there is no established treatment. We investigated whether azithromycin could control lymphocytic airway inflammation and improve allograft function. Fifteen lung transplant recipients demonstrating acute allograft
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American journal of physiology. Lung cellular and molecular physiology, 307(12), L948-L958 (2014-10-12)
Bronchopulmonary dysplasia (BPD) is the chronic lung disease of prematurity that affects very preterm infants. Although advances in perinatal care have enabled the survival of infants born as early as 23-24 wk of gestation, the challenge of promoting lung growth

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