所有图片(2)
About This Item
经验公式（希尔记法）:
C10H20N2O2
CAS号:
分子量:
200.28
MDL编号:
UNSPSC代码:
12352100
PubChem化学物质编号:
NACRES:
NA.22
推荐产品
质量水平
方案
97%
表单
solid
SMILES字符串
CC(C)(C)OC(=O)N1CCC(N)CC1
InChI
1S/C10H20N2O2/c1-10(2,3)14-9(13)12-6-4-8(11)5-7-12/h8H,4-7,11H2,1-3H3
InChI key
LZRDHSFPLUWYAX-UHFFFAOYSA-N
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应用
4-氨基-1-Boc-哌啶可用于：
- 作为合成N-（3-（4-羟苯基）-丙烯酰基）-氨基酸类色胺的原料，该产物可用作沉默信息调节剂人2型（SIRT2）抑制剂
- 合成哌啶取代的三嗪衍生物和哌啶基氨基-二芳基嘧啶（pDAPY）衍生物，这些衍生物可作为有效的HIV-1非核苷逆转录酶抑制剂（HIV-1 NNRTIs）
通过伯胺与树脂结合型二甲磺酸盐直接成环，用于N-取代哌啶的微波辅助固相合成。
警示用语：
Danger
危险分类
Acute Tox. 4 Oral - Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
储存分类代码
11 - Combustible Solids
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
Calum Macleod et al.
Journal of combinatorial chemistry, 8(1), 132-140 (2006-01-10)
The microwave-assisted solid-phase synthesis of piperazines, 3,9-diazaspiro[5.5]undecanes and 2,9-diazaspiro[5.5]undecanes is reported. The synthesis relies on the direct annulation of primary amines with resin-bound bismesylates. Critical to the success of this chemistry was the development of alpha-methyl benzyl carbamate resin linker.
"Synthesis and biological evaluation of piperidine-substituted triazine derivatives as HIV-1 non-nucleoside reverse transcriptase inhibitors"
Chen X, et al.
European Journal of Organic Chemistry, 51, 60- 66 (2012)
"N-(3-(4-Hydroxyphenyl)-propenoyl)-amino acid tryptamides as SIRT2 inhibitors"
Kiviranta.HP, et al.
Bioorganic & Medicinal Chemistry, 17(09), 2448-2451 (2007)
"Novel piperidinylamino-diarylpyrimidine derivatives with dual structural conformations as potent HIV-1 non-nucleoside reverse transcriptase inhibitors"
Chen X, et al.
Bioorganic & Medicinal Chemistry, 23(24), 6593-6597 (2013)
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