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Merck
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文件

608033

Sigma-Aldrich

L-精氨酸-13C6,15N4 盐酸盐

99 atom % 13C, 99 atom % 15N, 95% (CP)

别名:

SILAC氨基酸, (S)-(+)-2-氨基-5-[(氨基甲基)氨基]戊酸-13C6,15N4盐酸盐, 13C和15标记的精氨酸, 13C和15标记的精氨酸盐酸盐

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About This Item

线性分子式:
H215N13C(15NH)15NH(13CH2)313CH(15NH2)13CO2H · HCl
CAS号:
202468-25-5
分子量:
220.59
MDL编号:
MFCD04118221
UNSPSC代码:
12352209
PubChem化学物质编号:
329759227
NACRES:
NA.12

同位素纯度

99 atom % 13C
99 atom % 15N

质量水平

200

检测方案

95% (CP)

形式

solid

旋光性

[α]20/D +22°, c = 12 in 10% HCl

组成

L-isomer, 97%

技术

bio NMR: suitable
protein expression: suitable

mp

226-230 °C (dec.) (lit.)

质量偏移

M+10

SMILES字符串

Cl.[15NH2][13C@@H]([13CH2][13CH2][13CH2][15NH][13C]([15NH2])=[15NH])[13C](O)=O

InChI

1S/C6H14N4O2.ClH/c7-4(5(11)12)2-1-3-10-6(8)9;/h4H,1-3,7H2,(H,11,12)(H4,8,9,10);1H/t4-;/m0./s1/i1+1,2+1,3+1,4+1,5+1,6+1,7+1,8+1,9+1,10+1;

InChI key

KWTQSFXGGICVPE-YAUSPDTOSA-N

相关类别

应用

脉冲稳定同位素标记氨基酸已用于研究HIV-1感染人单核细胞来源巨噬细胞的宿主细胞功能、存活和准确的胞内蛋白合成途径。

包装

该产品有大量储备，可按需包装。 有关定价、供货和包装的信息，请联系稳定同位素客户服务。

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

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Alex A Makarov et al.
Nature communications, 10(1), 3056-3056 (2019-07-13)
Lamin A is a nuclear intermediate filament protein critical for nuclear architecture and mechanics and mutated in a wide range of human diseases. Yet little is known about the molecular architecture of lamins and mechanisms of their assembly. Here we
Roberto Ravasio et al.
Science advances, 6(15), eaax2746-eaax2746 (2020-04-15)
The histone demethylase LSD1 is deregulated in several tumors, including leukemias, providing the rationale for the clinical use of LSD1 inhibitors. In acute promyelocytic leukemia (APL), pharmacological doses of retinoic acid (RA) induce differentiation of APL cells, triggering degradation of
Stephanie D Kraft-Terry et al.
Journal of proteome research, 10(6), 2852-2862 (2011-04-20)
Dynamic interactions between human immunodeficiency virus-1 (HIV-1) and the macrophage govern the tempo of viral dissemination and replication in its human host. HIV-1 affects macrophage phenotype, and the macrophage, in turn, can modulate the viral life cycle. While these processes
Vittoria Matafora et al.
STAR protocols, 1(3), 100162-100162 (2020-12-31)
Secretome analysis is crucial to unravel extracellular processes. However, secreted proteins are difficult to detect in mass-spectrometry-based analysis due to contamination of serum proteins deriving from cell culture media and to high glycosylation, which hampers tryptic digestion. Secret3D workflow is
Zehan Hu et al.
Cell reports, 28(13), 3486-3496 (2019-09-26)
The target of rapamycin complex 1 (TORC1) is a master regulator of cell homeostasis, which promotes anabolic reactions and synchronously inhibits catabolic processes such as autophagy-mediated protein degradation. Its prime autophagy target is Atg13, a subunit of the Atg1 kinase
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