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Merck
CN

58790

Sigma-Aldrich

(+)-Ds-苏式-异柠檬酸二氢钾

≥98.0% (NT)

别名:

(1R,2S)-1-羟基-1,2,3-丙烷三羧酸 单钾盐, Ds-(+)-苏式-异柠檬酸 单钾盐

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About This Item

经验公式(希尔记法):
C6H7KO7
CAS号:
分子量:
230.21
Beilstein:
3767339
UNSPSC代码:
51113400
PubChem化学物质编号:
NACRES:
NA.22

质量水平

检测方案

≥98.0% (NT)

旋光性

[α]20/D +20.5±1°, c = 2% in H2O

mp

~185 °C (dec.)

SMILES字符串

[K+].O[C@H]([C@H](CC(O)=O)C([O-])=O)C(O)=O

InChI

1S/C6H8O7.K/c7-3(8)1-2(5(10)11)4(9)6(12)13;/h2,4,9H,1H2,(H,7,8)(H,10,11)(H,12,13);/q;+1/p-1/t2-,4+;/m0./s1

InChI key

IVLPTBJBFVJENN-LEJBHHMKSA-M

应用

(+)-Ds-苏式-异柠檬酸钾可用于通过Kornberg方法对异柠檬酸脱氢酶2(Idh2)的活性进行评估。

包装

无底玻璃瓶。内含物在插入的融合锥体内。

其他说明

用作鉴定异柠檬酸脱氢酶时的底物

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)


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Sarah E Anderson et al.
The Analyst, 145(11), 3899-3908 (2020-04-17)
The enzyme isocitrate dehydrogenase 1 (IDH1) catalyzes the conversion of isocitrate to alpha-ketoglutarate (αKG) and has emerged as an important therapeutic target for glioblastoma multiforme (GBM). Current methods for assaying IDH1 remain poorly suited for high-throughput screening of IDH1 antagonists.
Sequential actions of SIRT1-RELB-SIRT3 coordinate nuclear-mitochondrial communication during immunometabolic adaptation to acute inflammation and sepsis.
Liu TF, et al.
The Journal of Biological Chemistry, 290(1), 396-408 (2015)
H Eguchi et al.
Biochimica et biophysica acta, 990(2), 133-137 (1989-02-24)
NADP-dependent isocitrate dehydrogenase (EC 1.1.1.42) was purified to electrophoretic homogeneity from an extremely thermophilic bacterium, Thermus thermophilus HB8, and shown to be a dimeric protein of molecular weight 115,000, with a pI of 5.5. The amino acid composition of the
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Ashley S Williams et al.
Cell metabolism, 31(1), 131-147 (2019-12-10)
This study sought to examine the functional significance of mitochondrial protein acetylation using a double knockout (DKO) mouse model harboring muscle-specific deficits in acetyl-CoA buffering and lysine deacetylation, due to genetic ablation of carnitine acetyltransferase and Sirtuin 3, respectively. DKO

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