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Merck
CN

56485

N-羟基硫代琥珀酰亚胺 钠盐

≥98% (HPLC), for peptide synthesis

别名:

磺基-NHS, 羟基-2,5-二氧代吡咯烷-3-磺酸 钠盐

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关于此项目

经验公式（希尔记法）:
C4H4NNaO6S
化学文摘社编号:
106627-54-7
分子量:
217.13
NACRES:
NA.22
PubChem Substance ID:
57651582
UNSPSC Code:
12352005
MDL number:
MFCD00043100
Beilstein/REAXYS Number:
6359129

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产品名称

N-羟基硫代琥珀酰亚胺 钠盐, ≥98% (HPLC)

InChI

1S/C4H5NO6S.Na/c6-3-1-2(12(9,10)11)4(7)5(3)8;/h2,8H,1H2,(H,9,10,11);/q;+1/p-1

SMILES string

[Na+].ON1C(=O)CC(C1=O)S([O-])(=O)=O

InChI key

RPENMORRBUTCPR-UHFFFAOYSA-M

assay

≥98% (HPLC)

form

powder

composition

carbon, 20.90-22.68 (anhydrous)
nitrogen, 6.10-6.61 (anhydrous)

reaction suitability

reaction type: Addition Reactions

impurities

≤4% water

application(s)

peptide synthesis

functional group

imide
sulfonic acid

Quality Level

200

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相关类别

Application

N-羟基磺基琥珀酰亚胺钠盐是N-羟基琥珀酰亚胺的一种水溶性磺化类似物。它可以在碳二亚胺如1-乙基-3-（3-二甲基氨基丙基）碳二亚胺（EDC）存在时与羧酸发生偶联反应，形成亲水性的N-羟基磺基琥珀酰亚胺活性酯。这些酯可用于蛋白的交联实验。

Other Notes

磺基-NHS可用于制备亲水性活性酯，如用于交联剂

Packaging

无底玻璃瓶。内含物装在插入的融合锥内。

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
BCCP0330
WXBF7846V
BCCM7829
WXBF5621V
WXBF5173V

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N-hydroxysulfosuccinimide active esters: bis (N-hydroxysulfosuccinimide) esters of two dicarboxylic acids are hydrophilic, membrane-impermeant, protein cross-linkers.
Staros JV
Biochemistry, 21(17), 3950-3955 (1982)
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P S Anjaneyulu et al.
International journal of peptide and protein research, 30(1), 117-124 (1987-07-01)
N-Hydroxysulfosuccinimide esters are reactive functional groups employed in a variety of protein modification reagents, especially cross-linking reagents. For these compounds, hydrolysis is the most important reaction competing for reaction of the esters with nucleophilic groups in proteins. We have employed
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