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Merck
CN

563382

Sigma-Aldrich

(R)-(+)-(3-氯苯基)环氧乙烷

别名:

(R)-(+)-(3-Chlorophenyl)oxirane

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About This Item

经验公式(希尔记法):
C8H7ClO
CAS号:
分子量:
154.59
MDL编号:
UNSPSC代码:
12352005
PubChem化学物质编号:
NACRES:
NA.22

旋光性

[α]20/D +19°, neat

折射率

n20/D 1.551 (lit.)

沸点

67-68 °C/1 mmHg (lit.)

密度

1.214 g/mL at 25 °C (lit.)

官能团

chloro
ether

SMILES字符串

Clc1cccc(c1)[C@@H]2CO2

InChI

1S/C8H7ClO/c9-7-3-1-2-6(4-7)8-5-10-8/h1-4,8H,5H2/t8-/m0/s1

InChI key

YVMKRPGFBQGEBF-QMMMGPOBSA-N

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应用

(R)-(+)-3-Chlorostyrene oxide may be used as an intermediate for the synthesis of 4-aminopiperidine based human β3-adrenergic receptor (AR) agonists.
Reactant involved in:
  • Diastereoselective Wadsworth-Emmons cyclopropanation for synthesis of quaternaty cyclopropyl esters
  • Synthesis of phenylethanolamine derivatives as β3-adrenergic receptor agonists
  • Stereoselective ring-opening for synthesis of β-aryloxy-substituted alcohols and amines
  • Synthesis of Biphenyl benzoic acid derivatives as β3-adrenergic receptor agonists
  • Synthesis of (S)-2-, 3-, and 4-chlorostyrene oxides with epoxide hydrolase

象形图

Exclamation mark

警示用语:

Warning

危险分类

Eye Irrit. 2 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3

靶器官

Respiratory system

储存分类代码

10 - Combustible liquids

WGK

WGK 3

闪点(°F)

206.6 °F - closed cup

闪点(°C)

97 °C - closed cup

个人防护装备

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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4-Aminopiperidine ureas as potent selective agonists of the human ? 3-Adrenergic receptor.
Ashwell MA, et al.
Bioorganic & Medicinal Chemistry Letters, 11(24), 3123-3127 (2001)

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