55100
8-羟基喹啉 半硫酸盐
≥98.0% (dry substance, T), yellow
别名:
8-氢氧化喹啉 半硫酸盐
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关于此项目
经验公式（希尔记法）:
C18H14N2O2 · H2SO4
化学文摘社编号:
分子量:
388.39
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
EC Number:
205-137-1
Beilstein/REAXYS Number:
3760550
MDL number:
Assay:
≥98.0% (dry substance, T)
InChI key
YYVFXSYQSOZCOQ-UHFFFAOYSA-N
InChI
1S/2C9H7NO.H2O4S/c2*11-8-5-1-3-7-4-2-6-10-9(7)8;1-5(2,3)4/h2*1-6,11H;(H2,1,2,3,4)
SMILES string
OS(O)(=O)=O.Oc1cccc2cccnc12.Oc3cccc4cccnc34
description
C9H7NO · ½H2SO4 (Linear Formula)
assay
≥98.0% (dry substance, T)
impurities
~5% water
color
yellow
antibiotic activity spectrum
fungi
mode of action
DNA synthesis | interferes, enzyme | inhibits
General description
化学结构：喹诺酮类
Application
8-羟基喹啉半硫酸盐 (8-OHQ) 可用于制备具有蛋白酶抑制活性的 Cu [8-OHQ] 2。
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
存储类别
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Kenyon G Daniel et al.
Biochemical pharmacology, 67(6), 1139-1151 (2004-03-10)
Here we report that organic copper complexes can potently and selectively inhibit the chymotrypsin-like activity of the proteasome in vitro and in vivo. Several copper compounds, such as NCI-109268 and bis-8-hydroxyquinoline copper(II) [Cu(8-OHQ)(2)], can inhibit the chymotrypsin-like activity of purified
Meng Zhang et al.
Inorganic chemistry, 51(21), 11315-11323 (2012-10-09)
An artificial peptide with three pendant hydroxyquinoline (hq) ligands on a palindromic backbone was designed and used to form multimetallic assemblies. Reaction of the tripeptide with zinc acetate led to a highly fluorescent tripeptide duplex with three Zn(II) coordinative cross-links.
Ping Nan et al.
Environmental toxicology and pharmacology, 35(3), 434-443 (2013-03-12)
This study was a preliminary step in evaluating the genotoxic effects of 8-hydroxylquinoline (8-HOQ) in loach (Misgurnus anguillicaudatus) using the micronucleus, comet and RAPD assays. In the micronucleus test and comet assay, the micronuclei rate (%) and three comet parameters
Bhimashankar Mitkari et al.
Experimental neurology, 239, 158-162 (2012-10-13)
Cell therapies from various sources have been under intense research in stroke. Efficient homing of the cells to the injured brain without complications is necessary to realize the therapeutic potential of cell therapy. Intra-arterial (IA) infusion of cells bypasses the
Steve Comby et al.
Inorganic chemistry, 51(19), 10158-10168 (2012-09-15)
A novel near-infrared (NIR) emissive lanthanide-based zinc sensor was designed, based on the self-assembly in aqueous solution between the nonemissive coordinatively unsaturated Yb(III) cyclen complex 2·Yb and the sulfonated 8-hydroxyquinoline (8-HQS) chromophore, which was employed as a sensitizing antenna. The
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