InChI key
RFYDWSNYTVVKBR-UHFFFAOYSA-N
InChI
1S/C10H18Cl2O2/c1-2-14-10(13)6-4-3-5-9(12)7-8-11/h9H,2-8H2,1H3
SMILES string
CCOC(=O)CCCCC(Cl)CCCl
assay
95%
refractive index
n20/D 1.462 (lit.)
density
1.107 g/mL at 25 °C (lit.)
Application
6,8-二氯辛酸乙酯可用作合成6-硒代硫辛酸和α-硫辛酸衍生物的原料，而这些衍生物表现出了有效的抗癌活性。
其还可用作合成以下成分的起始材料：
其还可用作合成以下成分的起始材料：
- 6,8-二苄基巯基辛酸，一种用于制备 DL-α-硫辛酸的中间体。
- 5,7-二氯庚酸乙酯，一种用于制备 DL-1,2-二硫杂环戊酸酯-3-丁酸的中间体。
- 7-溴-1,3-二氯庚烷，一种制备 DL-12-二硫杂环戊酸酯-3-丁烷磺酰胺的中间体。
signalword
Warning
hcodes
Hazard Classifications
Aquatic Chronic 2 - Skin Sens. 1
存储类别
10 - Combustible liquids
wgk
WGK 2
flash_point_f
230.0 °F - closed cup
flash_point_c
110 °C - closed cup
ppe
Eyeshields, Gloves, type ABEK (EN14387) respirator filter
法规信息
新产品
此项目有
Synthesis of some monoselenolipoic acid derivatives and their biological evaluation as anticancer agents.
Xu F, et al.
J. Chem. Res. (M), 37(5), 311-314 (2013)
Syntheses of DL-a-lipoic acid.
Reed LJ and Niu CI.
Journal of the American Chemical Society, 77(2), 416-419 (1955)
Synthesis of DL-1, 2-Dithiolane-3-caproic Acid and DL-1, 2-Dithiolane-3-butyric Acid, Homologs of a-Lipoic Acid.
Thomas RC and Reed LJ.
Journal of the American Chemical Society, 78(23), 6151-6153 (1956)
Synthesis of DL-1, 2-Dithiolane-3-butanesulfonamide, an Analog of a-Lipoic Acid.
Thomas RC and Reed LJ.
Journal of the American Chemical Society, 78(23), 6150-6151 (1956)
Shi-Jie Zhang et al.
Bioorganic & medicinal chemistry letters, 20(10), 3078-3083 (2010-04-21)
alpha-Lipoic acid derivatives were synthesized and evaluated for their in vitro anticancer activities against NCI-460, HO-8910, KB, BEL-7402, and PC-3 cell lines. The results, for most compounds exhibited dose-dependent inhibitory property and several compounds had good inhibitions at the dose
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