产品名称
PAMAM-OH 树枝状聚合物，第6代 溶液, 5 wt. % in methanol
description
amidoethanol surface groups
form
liquid
mol wt
generation 6
feature
core type ethylenediamine core (2-carbon core)
concentration
5 wt. % in methanol
no. Surface Groups
256
refractive index
n20/D 1.336
density
0.807 g/mL at 25 °C
storage temp.
2-8°C
Quality Level
Legal Information
Dendritech®, Inc. 制造
使用及制造受 Dow Chemical Company 拥有的专利所保护。
使用及制造受 Dow Chemical Company 拥有的专利所保护。
Dendritech is a registered trademark of Dendritech, Inc.
Physical form
含有 256 个表面羟基。
Application
PAMAM-OH dendrimer can be used to formulate poorly water-soluble drugs to increase water solubility, and therefore enhance the bioavailability of these drugs. It can also be applied to catalysts and organic molecules, where dendrimers function as solubility enhancers and modifiers.
General description
PAMAM-OH (poly(amidoamine) dendrimers are highly branched core-shell nanostructures with surface hydroxyl groups. The presence of hydroxyl groups on the surface of the PAMAM-OH dendrimer molecule leads to stronger interaction with the components of the cell membrane via the formation of hydrogen bonds. This type of interaction can modify the properties and function of cell membranes. PAMAM-OH dendrimers also have an advantage over PAMAM dendrimers in terms of cytotoxicity and aggregation problems because of the absence of amine functionality.
signalword
Danger
Hazard Classifications
Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
target_organs
Eyes
存储类别
3 - Flammable liquids
wgk
WGK 3
flash_point_f
51.8 °F - closed cup
flash_point_c
11 °C - closed cup
法规信息
危险化学品
此项目有
Comparative pharmacokinetics of PAMAM-OH dendrimers and HPMA copolymers in ovarian tumor-bearing mice
Sadekar S, et al.
Drug delivery and translational research, 3(3), 260-271 (2013)
Synthesis and characterization of Cu, Ag and Au dendrimer-encapsulated nanoparticles and their application in the reduction of 4-nitrophenol to 4-aminophenol
Nemanashi M and Meijboom R
Journal of Colloid and Interface Science, 389(1), 260-267 (2013)
Polyamidoamine dendrimers for enhanced solubility of small molecules and other desirable properties for site-specific delivery: Insights from experimental and computational studies
Shadrack DM, et al.
Molecules (Basel), 23(6), 1419-1419 (2018)
Polyplexes assembled with internally quaternized PAMAM-OH dendrimer and plasmid DNA have a neutral surface and gene delivery potency
Lee Jung Hoon, et al.
Bioconjugate Chemistry, 14(6), 1214-1221 (2003)
The influence of PAMAM-OH dendrimers on the activity of human erythrocytes ATPases
Ciolkowski M, et al.
Biochimica et Biophysica Acta - Biomembranes, 1808(11), 2714-2723 (2011)
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