所有图片(1)
About This Item
线性分子式:
[NH2(CH2)2NH2]:(G=6);dendri PAMAM(NHCH2CH2OH)256
分子量:
58298.21
MDL编号:
UNSPSC代码:
12162002
NACRES:
NA.25
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描述
amidoethanol surface groups
质量水平
表单
liquid
分子量
generation 6
特点
core type ethylenediamine core (2-carbon core)
浓度
5 wt. % in methanol
表面基团编号
256
折射率
n20/D 1.336
密度
0.807 g/mL at 25 °C
储存温度
2-8°C
一般描述
PAMAM-OH (poly(amidoamine) dendrimers are highly branched core-shell nanostructures with surface hydroxyl groups. The presence of hydroxyl groups on the surface of the PAMAM-OH dendrimer molecule leads to stronger interaction with the components of the cell membrane via the formation of hydrogen bonds. This type of interaction can modify the properties and function of cell membranes. PAMAM-OH dendrimers also have an advantage over PAMAM dendrimers in terms of cytotoxicity and aggregation problems because of the absence of amine functionality.
应用
PAMAM-OH dendrimer can be used to formulate poorly water-soluble drugs to increase water solubility, and therefore enhance the bioavailability of these drugs. It can also be applied to catalysts and organic molecules, where dendrimers function as solubility enhancers and modifiers.
外形
含有 256 个表面羟基。
法律信息
Dendritech®, Inc. 制造
使用及制造受 Dow Chemical Company 拥有的专利所保护。
使用及制造受 Dow Chemical Company 拥有的专利所保护。
Dendritech is a registered trademark of Dendritech, Inc.
警示用语：
Danger
危险分类
Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
靶器官
Eyes
储存分类代码
3 - Flammable liquids
WGK
WGK 3
闪点(°F)
51.8 °F - closed cup
闪点(°C)
11 °C - closed cup
法规信息
危险化学品
Comparative pharmacokinetics of PAMAM-OH dendrimers and HPMA copolymers in ovarian tumor-bearing mice
Sadekar S, et al.
Drug delivery and translational research, 3(3), 260-271 (2013)
Polyamidoamine dendrimers for enhanced solubility of small molecules and other desirable properties for site-specific delivery: Insights from experimental and computational studies
Shadrack DM, et al.
Molecules (Basel), 23(6), 1419-1419 (2018)
Synthesis and characterization of Cu, Ag and Au dendrimer-encapsulated nanoparticles and their application in the reduction of 4-nitrophenol to 4-aminophenol
Nemanashi M and Meijboom R
Journal of Colloid and Interface Science, 389(1), 260-267 (2013)
Polyplexes assembled with internally quaternized PAMAM-OH dendrimer and plasmid DNA have a neutral surface and gene delivery potency
Lee Jung Hoon, et al.
Bioconjugate Chemistry, 14(6), 1214-1221 (2003)
The influence of PAMAM-OH dendrimers on the activity of human erythrocytes ATPases
Ciolkowski M, et al.
Biochimica et Biophysica Acta - Biomembranes, 1808(11), 2714-2723 (2011)
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