534498
4-哌啶基哌啶
97%
别名:
1,4′-二哌啶
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关于此项目
经验公式（希尔记法）:
C10H20N2
化学文摘社编号:
分子量:
168.28
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352100
EC Number:
225-522-8
MDL number:
Assay:
97%
InChI key
QDVBKXJMLILLLB-UHFFFAOYSA-N
InChI
1S/C10H20N2/c1-2-8-12(9-3-1)10-4-6-11-7-5-10/h10-11H,1-9H2
SMILES string
C1CCN(CC1)C2CCNCC2
assay
97%
mp
64-66 °C (lit.)
storage temp.
−20°C
Quality Level
Gene Information
rat ... Grin2a(24409)
Application
药物化学试剂。
Reactant for synthesis of:
Arylthiadiazole H3 antagonists
Water-soluble N-mustards as anticancer agents
Antitubercular drugs
Vasopressin1b receptor antagonists
MDR modulators
Selective Norepinephrine transporter inhibitors
Arylthiadiazole H3 antagonists
Water-soluble N-mustards as anticancer agents
Antitubercular drugs
Vasopressin1b receptor antagonists
MDR modulators
Selective Norepinephrine transporter inhibitors
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
法规信息
新产品
此项目有
Yuqiang Wang et al.
Bioorganic & medicinal chemistry, 13(19), 5592-5599 (2005-08-09)
We have synthesized a conjugate of cis-4,7,10,13,16,19-docosahexenoic acid (DHA) and 10-hydroxycamptothecin (HCPT), DHA-HCPT. The antitumor activity of DHA-HCPT was evaluated in vitro against L1210 leukemia cells and in experimental animal tumor models including L1210 leukemia, Lewis lung carcinoma, and colon
Hidetsura Cho et al.
Journal of medicinal chemistry, 47(1), 101-109 (2003-12-30)
A variety of novel heterocyclic compounds having thienoazepine, pyrroloazepine, furoazepine, and thienodiazepine skeletons were synthesized, most of which exhibited potent antagonism of [(3)H]-AVP specific binding in assays using rat liver (V1), rat kidney (V2), human platelet plasma membranes, and recombinant
Synlett, 8, 1192-1194 (2003)
Janice L Hyatt et al.
Chemico-biological interactions, 157-158, 247-252 (2005-11-01)
CPT-11 (irinotecan, 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin) is an anticancer prodrug that has been approved for the treatment of colon cancer. It is a member of the camptothecin class of drugs and activation to the active metabolite SN-38, is mediated by carboxylesterases (CE). SN-38
José M Quintela et al.
European journal of medicinal chemistry, 38(3), 265-275 (2003-04-02)
New antiprotozoals active against Philasterides dicentrarchi, the causative agent of scuticociliatosis in farmed turbot and Black Sea bass-bream, have been synthesised and tested. The most active compounds posses a piperazine ring, generally N-bonded to the heterocycle, and are the 1,8-naphthyridines
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