所有图片(2)
别名:
2-Chloro-1H-isoindole-1,3(2H)-dione, 2-Chloro-2,3-dihydro-1H-isoindole-1,3-dione, 2-Chloroisoindole-1,3-dione, 2-Chloroisoindoline-1,3-dione, Phthalimide chloride, Phthalimidoyl chloride
经验公式（希尔记法）:
C8H4ClNO2
CAS号:
分子量:
181.58
EC 号:
MDL编号:
UNSPSC代码:
12352100
PubChem化学物质编号:
NACRES:
NA.22
推荐产品
质量水平
检测方案
96%
mp
188-198 °C (lit.)
SMILES字符串
ClN1C(=O)c2ccccc2C1=O
InChI
1S/C8H4ClNO2/c9-10-7(11)5-3-1-2-4-6(5)8(10)12/h1-4H
InChI key
WDRFYIPWHMGQPN-UHFFFAOYSA-N
一般描述
N-Chlorophthalimide in anhydrous acetic acid serves as a useful oxidizing reagent for use in various direct titrimetric analyses. N-Chlorophthalimide can be synthesized by reacting phthalimide, t-butyl hypochlorite, water and t-butyl alcohol. It participates in the synthesis of 2-amino-3-benzoyl-α-(methylthio)phenylacetamide.
应用
N-Chlorophthalimide may be employed in the synthesis of:
- α-amino acetal
- α-amino nitro compounds
- vicinal diamine
- α,β-unsaturated vicinal haloamino nitro compound
警示用语：
Warning
危险声明
危险分类
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
法规信息
新产品
Aminochlorination reaction with N-chlorophthalimide as a new nitrogen/chlorine source resulting in a-amino derivatives.
Qian Y, et al.
Tetrahedron, 68(31), 6198-6203 (2012)
N Jayasree et al.
Talanta, 32(11), 1067-1068 (1985-11-01)
A stable new oxidimetric titrant, N-chlorophthalimide in anhydrous acetic acid, is proposed for direct titrations of a variety of simple and complex reductants such as As(III), Sb(III), Fe(II), ferrocyanide, iodide, ascorbic acid, hydroquinone, hydrazine, phenylhydrazine, benzhydrazide, isonicotinic acid hydrazide, semicarbazide
N-Chlorophthalimide as a mild and efficient chlorination reagent in the Gassman ortho alkylation of aromatic amines. Synthesis of 3-(methylthio) oxindoles.
Cybulski M, et al.
Tetrahedron Letters, 55(40), 5423-5425 (2014)
Tertiary Butyl Hypochlorite as as N-Chlorinating Agent.
Zimmer H and Audrieth LF.
Journal of the American Chemical Society, 76(14), 3856-3857 (1954)
Development and a practical synthesis of nepafenac intermediate via modified Gassman reaction.
Cybulski M, et al.
Letters in Organic Chemistry, 9(7), 461-464 (2012)
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