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浓度
2.0 M in diethyl ether
密度
0.773 g/mL at 25 °C
储存温度
2-8°C
SMILES字符串
C[Si](C)(C)C=[N+]=[N-]
InChI
1S/C4H10N2Si/c1-7(2,3)4-6-5/h4H,1-3H3
InChI key
ONDSBJMLAHVLMI-UHFFFAOYSA-N
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一般描述
(三甲基硅烷基)重氮甲烷被认为是重氮甲烷的非爆炸性替代物,用于羰基衍生物(主要是酮)通过反应(如 Tiffeneau-Demjanov 重排)的同系化。
应用
反应物用于制备:
- 改善代谢稳定性和抗菌活性的天然产物大环内酯 (-)-A26771B 的大内酰胺类似物
- 白霉素 D 类似物作为蛋白激酶抑制剂用于肿瘤治疗
- 非天然 α-含 gem-二膦酸盐的氨基酸衍生物通过 Michael 加成反应
- 作为潜在透明质酸酶底物的封端 4-甲基伞形酮基透明质酸二糖和四糖
- Stictamides A-C 作为具有抗肿瘤侵袭活性的基质金属肽酶 12 (MMP12) 抑制剂
- 内皮素转换酶 (ECE) 抑制剂 WS 75624A 和 WS 75624B(通过交叉转移方法)
- 贝壳杉烯衍生物作为抗炎剂
- 毛叶假鹰爪素 C 类似物作为强效抗肿瘤药物通过激活纺锤体组装检查点发挥作用
- 咪唑并 [2,1-b] 苯并噻唑衍生物作为潜在的 p53 抑制剂
相关产品
产品编号
说明
价格
警示用语:
Danger
危险分类
Acute Tox. 2 Inhalation - Acute Tox. 4 Oral - Carc. 1B - Flam. Liq. 2 - STOT SE 1 Inhalation - STOT SE 3
靶器官
Central nervous system, Lungs
补充剂危害
WGK
WGK 3
闪点(°F)
closed cup
闪点(°C)
closed cup
个人防护装备
Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
法规信息
监管及禁止进口产品
A new, stable, and safe reagent for the homologation of ketones.
Tetrahedron Letters, 21(48), 4619-4622 (1980)
Archives of biochemistry and biophysics, 467(2), 144-153 (2007-09-25)
The reversible redox chemistry of coenzyme Q serves a crucial function in respiratory electron transport. Biosynthesis of Q in Escherichia coli depends on the ubi genes. However, very little is known about UbiX, an enzyme thought to be involved in
Homologation reaction of ketones with diazo compounds.
Chemical Reviews, 116(5), 2937-2981 (2016)
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 881-882, 34-41 (2011-12-27)
Risedronate is a commonly prescribed bisphosphonate for the treatment of bone disorders. Due to its high polarity and low oral bioavailability, low concentrations of risedronate are expected in human plasma and therefore a sensitive assay is required to serve in
Electrophoresis, 23(14), 2327-2332 (2002-09-05)
The investigation of emerging contaminant issues is a proactive effort in environmental analysis. As a part of this effort, sewage effluent is of current analytical interest because of the presence of pharmaceuticals and their metabolites and personal care products. The
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