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质量水平
检测方案
≥99%
bp
195 °C/733 mmHg (lit.)
密度
1.047 g/mL at 25 °C (lit.)
SMILES字符串
OCC(O)C=C
InChI
1S/C4H8O2/c1-2-4(6)3-5/h2,4-6H,1,3H2
InChI key
ITMIAZBRRZANGB-UHFFFAOYSA-N
一般描述
3,4-二羟基-1-丁烯,也称为3-丁烯-1,2-二醇(BDdiol),是1,3-丁二烯的代谢产物。 它形成用于合成不同手性结构单元的前体。 BDdiol经过氧化,形成羟甲基乙烯基酮(HMVK)。 在环氧化物水解酶(EH)存在下,1,2-环氧-3-丁烯(EB)水解形成BDdiol。
应用
使用3,4-二羟基-1-丁烯:
- 作为反应剂以通过连续流过程合成循环有机碳酸酯。
- 制备用于定向药物相关RNA的取代恶唑烷酮配体。
警示用语:
Warning
危险分类
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
Versatile and scalable synthesis of cyclic organic carbonates under organocatalytic continuous flow conditions
Catalysis Science & Technology, 9(24), 6841-6851 (2019)
3-Butene-1, 2-diol: An attractive precursor for the synthesis of enantiomerically pure organic compounds.
Tetrahedron, 45(22), 7031-7040 (1989)
Chemical research in toxicology, 17(6), 819-826 (2004-06-23)
3-Butene-1,2-diol (BDD), a major metabolite of 1,3-butadiene (BD), can readily be oxidized to hydroxymethylvinyl ketone (HMVK), a Michael acceptor. In previous studies, 4-(N-acetyl-l-cystein-S-yl)-1,2-dihydroxybutane (DHB), a urinary metabolite of BD that was used to assess human BD exposure, was suggested to
Chemico-biological interactions, 135-136, 249-265 (2001-06-09)
First-pass metabolism of 1,3-butadiene (BD) leading to 1,2-epoxy-3-butene (EB), 1,2:3,4-diepoxybutane (DEB), 3-butene-1,2-diol (B-diol), 3,4-epoxy-1,2-butanediol (EBD) and crotonaldehyde (CA) was studied quantitatively in the once-through BD perfused liver of mouse and rat by means of an all-glass gas-tight perfusion system. Metabolites
Journal of medicinal chemistry, 54(19), 6786-6795 (2011-08-05)
The enantiomers and the cis isomers of two previously studied 4,5-disubstituted oxazolidinones have been synthesized, and their binding to the T-box riboswitch antiterminator model RNA has been investigated in detail. Characterization of ligand affinities and binding site localization indicates that
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