47695
芴甲氧羰基-S-三苯甲基-L-半胱氨酸
≥95.0% (sum of enantiomers, HPLC)
别名:
N-(9-芴甲氧羰基)-S-三苯甲基-L-半胱氨酸, Nα-Fmoc-S-三苯甲基-L-半胱氨酸
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关于此项目
经验公式（希尔记法）:
C37H31NO4S
化学文摘社编号:
分子量:
585.71
NACRES:
NA.26
PubChem Substance ID:
eCl@ss:
32160406
UNSPSC Code:
12352209
MDL number:
Beilstein/REAXYS Number:
4221286
InChI
1S/C37H31NO4S/c39-35(40)34(38-36(41)42-24-33-31-22-12-10-20-29(31)30-21-11-13-23-32(30)33)25-43-37(26-14-4-1-5-15-26,27-16-6-2-7-17-27)28-18-8-3-9-19-28/h1-23,33-34H,24-25H2,(H,38,41)(H,39,40)/t34-/m0/s1
SMILES string
OC(=O)[C@H](CSC(c1ccccc1)(c2ccccc2)c3ccccc3)NC(=O)OCC4c5ccccc5-c6ccccc46
InChI key
KLBPUVPNPAJWHZ-UMSFTDKQSA-N
assay
≥95.0% (sum of enantiomers, HPLC)
optical activity
[α]20/D +16.0±2°, c = 1% in THF
reaction suitability
reaction type: Fmoc solid-phase peptide synthesis
mp
170-173 °C (lit.)
application(s)
peptide synthesis
functional group
Fmoc
storage temp.
2-8°C
Quality Level
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General description
Fmoc-Cys(Trt)-OH是Fmoc固相肽合成中常用的氨基酸。
Application
Fmoc-Cys（Trt）-OH是一种N末端保护的半胱氨酸衍生物，可用于肽合成。一些例子包括：
- 合成单官能和双官能化铂（IV）络合物以靶向血管生成肿瘤脉管系统。
- 通过固相合成将肽酰肼作为硫酯替代物进行天然化学连接来合成蛋白质。
- 通过将还原糖与肽的半胱氨酸残基缀合来合成糖结合物。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Conjugated platinum (IV)? peptide complexes for targeting angiogenic tumor vasculature.
Mukhopadhyay S, et al.
Bioconjugate Chemistry, 19(1), 39-49 (2007)
Chemical synthesis of proteins using peptide hydrazides as thioester surrogates.
Zheng J S, et al.
Nature Protocols, 8(12), 2483-2483 (2013)
A double-click approach to the protecting group free synthesis of glycoconjugates.
Alexander S R, et al.
Organic & Biomolecular Chemistry, 16(8), 1258-1262 (2018)
Young In Choi et al.
Polymers, 11(4) (2019-04-10)
Polymeric micelles as drug delivery vehicles are popular owing to several advantages. In this study, a gemini amphiphile (gemini mPEG-Cys-PMT) consisting of hydrophilic poly(ethylene glycol) and hydrophobic poly(methionine) with cystine disulfide spacer was synthesized and its micellar properties for thiol-
Cathleen Jendrny et al.
Chembiochem : a European journal of chemical biology, 17(8), 719-726 (2015-11-18)
Serpin proteins irreversibly inhibit serine proteases, but only a small part of the serpin reactive-center loop (RCL) is responsible for the initial protein-protein interaction (PPI). To develop peptidic protease inhibitors, kallikrein-related peptidases 7 (KLK7) and 5 (KLK5) were chosen. Firstly
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