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主要文件

47625

Sigma-Aldrich

芴甲氧羰酰-色氨酸

≥98.0% (HPLC), for peptide synthesis

别名:

芴甲氧羰基-L-谷氨酸 5-叔丁酯

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About This Item

经验公式(希尔记法):
C24H27NO6
CAS号:
分子量:
425.47
Beilstein:
3636375
EC 号:
MDL编号:
UNSPSC代码:
12352209
eCl@ss:
32160406
PubChem化学物质编号:
NACRES:
NA.26

产品名称

芴甲氧羰酰-色氨酸, ≥98.0% (HPLC)

方案

≥98.0% (HPLC)

表单

powder

旋光性

[α]20/D −5.0±2.0°, c = 1% in acetic acid: water (4:1)

反应适用性

reaction type: Fmoc solid-phase peptide synthesis

杂质

~4% water

应用

peptide synthesis

官能团

Fmoc

储存温度

2-8°C

SMILES字符串

CC(C)(C)OC(=O)CC[C@H](NC(=O)OCC1c2ccccc2-c3ccccc13)C(O)=O

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717347174593206
Quality Level

200

Quality Level

200

Quality Level

100, 200

Quality Level

200

form

crystals

form

crystals

form

powder

form

solid

grade

for ion-selective electrodes

grade

for ion-selective electrodes

grade

for ion-selective electrodes

grade

for ion-selective electrodes

product line

Selectophore

product line

Selectophore

product line

Selectophore

product line

Selectophore

quality

function tested

quality

function tested

quality

function tested

quality

function tested

一般描述

Fmoc-Glu(OtBu)-OH 被广泛用于肽合成中保护胺基的合成嵌段。[1][2]

应用

Fmoc-Glu(OtBu)-OH(氧羰基-L-谷氨酸 5--丁酯)可用于:
  • 配体,以使用Pd催化剂通过环丙烷酰胺C-H活化反应合成顺式取代环丙烷羧酸。[3]
  • 多小分子共轭PTX(紫杉醇)衍生物制备中的连接剂。[4]

还可用作基本构成要素制备钉状α-螺旋肽[5]和肽C-端硫代酸酯[6]

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)


  • 历史批次信息供参考:

    分析证书(COA)

    Lot/Batch Number

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    访问文档库

    Solid phase synthesis of peptide C-terminal thioesters by Fmoc/t-Bu chemistry
    Ingenito R, et al.
    Journal of the American Chemical Society, 121(49), 11369-11374 (1999)
    Multi-small molecule conjugations as new targeted delivery carriers for tumor therapy
    Shan L, et al.
    International journal of nanomedicine, 10(49), 5571-5571 (2015)
    Stapled α-helical peptide drug development: A potent dual inhibitor of MDM2 and MDMX for p53-dependent cancer therapy
    Chang YS, et al.
    Proceedings of the National Academy of Sciences of the USA, 110(36), E3445-E3454 (2013)
    Synthesis of peptides from alpha-and beta-tubulin containing glutamic acid side-chain linked oligo-glu with defined length
    Tegge W, et al.
    International Journal of Peptides, 2010 (2010)
    Spectral characterization, solvation effects on topological aspects, and biological attributes of Fmoc-L-glutamic acid 5-tert-butyl ester: An effective reagent in anticancer evaluations
    Thirunavukkarasu M, et al.
    Journal of Molecular Structure, 1269, 133793-133793 (2022)

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