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Merck
CN

47618

Sigma-Aldrich

Fmoc-L-天冬氨酸4-叔丁酯

≥98.0% (HPLC), for peptide synthesis

别名:

Fmoc-L-天冬氨酸 4-叔丁酯

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About This Item

经验公式(希尔记法):
C23H25NO6
CAS号:
分子量:
411.45
Beilstein:
3635671
EC 号:
MDL编号:
UNSPSC代码:
12352209
eCl@ss:
32160406
PubChem化学物质编号:
NACRES:
NA.26

product name

Fmoc-L-天冬氨酸4-叔丁酯, ≥98.0% (HPLC)

质量水平

检测方案

≥98.0% (HPLC)

形式

powder

旋光性

[α]20/D −24±2°, c = 1% in DMF

反应适用性

reaction type: Fmoc solid-phase peptide synthesis

mp

148-150 °C (dec.)

应用

peptide synthesis

官能团

Fmoc

储存温度

2-8°C

SMILES字符串

CC(C)(C)OC(=O)C[C@H](NC(=O)OCC1c2ccccc2-c3ccccc13)C(O)=O

InChI

1S/C23H25NO6/c1-23(2,3)30-20(25)12-19(21(26)27)24-22(28)29-13-18-16-10-6-4-8-14(16)15-9-5-7-11-17(15)18/h4-11,18-19H,12-13H2,1-3H3,(H,24,28)(H,26,27)/t19-/m0/s1

InChI key

FODJWPHPWBKDON-IBGZPJMESA-N

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一般描述

Fmoc-Asp(OtBu)-OH又称为Fmoc-L-天冬氨酸4-叔丁酯,在固相多肽合成中用作Fmoc-氨基酸类保护基团。

应用

Fmoc-Asp(OtBu)-OH可用于在Fmoc肽固相合成中防止天冬氨酰亚胺副产物的形成。

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)


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New t-butyl based aspartate protecting groups preventing aspartimide formation in Fmoc SPPS
R Behrendt, et.al.
Journal of Peptide Science, 21, 680-687 (2015)
Fengyang Xu et al.
ACS applied materials & interfaces, 8(44), 29906-29914 (2016-10-21)
In this work, we reported the generation of a novel supramolecular hydrogelator from a peptide derivative which consisted of a structural motif (e.g., Fc-FF) for supramolecular self-assembly and a functional moiety (e.g., RGD) for integrin binding. Following self-assembly in water
Jisi Zhao et al.
Molecules (Basel, Switzerland), 24(4) (2019-03-03)
Photodynamic therapy (PDT) is an established therapeutic modality for the management of cancers. Conjugation with tumor-specific small molecule ligands (e.g., short peptides or peptidomimetics) could increase the tumor targeting of PDT agents, which is very important for improving the outcome
R Ashton Lavoie et al.
Biotechnology and bioengineering, 117(2), 438-452 (2019-10-28)
The clearance of host cell proteins (HCPs) is of crucial importance in biomanufacturing, given their diversity in composition, structure, abundance, and occasional structural homology with the product. The current approach to HCP clearance in the manufacturing of monoclonal antibodies (mAbs)
Stefan Eissler et al.
Journal of peptide science : an official publication of the European Peptide Society, 23(10), 757-762 (2017-06-22)
In solid-phase peptide synthesis, the nominal batch size is calculated using the starting resin substitution and the mass of the starting resin. The starting resin substitution constitutes the basis for the calculation of a whole set of important process parameters

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