质量水平
检测方案
98%
mp
143-147 °C (lit.)
SMILES字符串
Nc1ccnc(N)n1
InChI
1S/C4H6N4/c5-3-1-2-7-4(6)8-3/h1-2H,(H4,5,6,7,8)
InChI key
YAAWASYJIRZXSZ-UHFFFAOYSA-N
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Warning
危险声明
危险分类
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
法规信息
新产品
Wilhelm Maximilian Hützler et al.
Acta crystallographica. Section C, Structural chemistry, 71(Pt 3), 229-238 (2015-03-04)
The results of seven cocrystallization experiments of the antithyroid drug 6-methyl-2-thiouracil (MTU), C(5)H(6)N(2)OS, with 2,4-diaminopyrimidine, 2,4,6-triaminopyrimidine and 6-amino-3H-isocytosine (viz. 2,6-diamino-3H-pyrimidin-4-one) are reported. MTU features an ADA (A = acceptor and D = donor) hydrogen-bonding site, while the three coformers show
Wenbo Zhou et al.
European journal of medicinal chemistry, 96, 269-280 (2015-04-23)
Therapeutics of metastatic or triple-negative breast cancer are still challenging in clinical. Herein we demonstrated the design and optimization of a series of hybrid of 2,4-diaminopyrimidine and arylthiazole derivatives for their anti-proliferative properties against two breast cancer cell lines (MCF-7
Hydrogen-bonded supramolecular structures in co-crystals of ?-or ?-diketone enols with 2, 6-diaminopyridine or 2, 4-diaminopyrimidine.
Bertolasi V, et al.
New. J. Chem., 26(11), 1559-1566 (2002)
Christopher M Harris et al.
Bioorganic & medicinal chemistry letters, 20(1), 334-337 (2009-11-21)
We describe structure-based optimization of a series of novel 2,4-diaminopyrimidine MK2 inhibitors. Co-crystal structures (see accompanying Letter) demonstrated a unique inhibitor binding mode. Resulting inhibitors had IC(50) values as low as 19nM and moderate selectivity against a kinase panel. Compounds
Luke Mercer et al.
PLoS neglected tropical diseases, 5(2), e956-e956 (2011-02-25)
There is an urgent need to develop new, safe and effective treatments for human African trypanosomiasis (HAT) because current drugs have extremely poor safety profiles and are difficult to administer. Here we report the discovery of 2,4-diaminopyrimidines, exemplified by 4-[4-amino-5-(2-methoxy-benzoyl)-pyrimidin-2-ylamino]-piperidine-1-carboxylic
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