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质量水平
检测方案
97%
mp
197-200 °C (dec.) (lit.)
SMILES字符串
Cn1cc(C(O)=O)c2ccccc12
InChI
1S/C10H9NO2/c1-11-6-8(10(12)13)7-4-2-3-5-9(7)11/h2-6H,1H3,(H,12,13)
InChI key
HVRCLXXJIQTXHC-UHFFFAOYSA-N
一般描述
1-Methylindole-3-carboxylic acid is an indole derivative that can be prepared by the oxidation of 1-methylindole-3-aldehyde with alkaline potassium permanganate.
应用
- Reactant for preparation of bisindolyl pyrimidinones analogs of PKC inhibitor LY333531
- Reactant for preparation of (heteroaryl)(carboxamido)arylpyrrole derivatives as Cdc7 kinase inhibitors, antitumor and antiproliferative agents
- Reactant for preparation of (pyrrolidinylmethoxy)cyclohexanecarboxylic acids as antigen-4 (VLA-4) antagonists
- Reactant for preparation of EphB3 receptor tyrosine kinase inhibitors
- Reactant for preparation of pyrazolodiazepine derivatives as human P2X7 receptor antagonists
- Reactant for preparation of potent nonpeptidic urotensin II receptor agonists
- Reactant for preparation of pyrrolizidine esters, amides, and ureas as 5-HT4 receptor ligands
警示用语：
Warning
危险声明
危险分类
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
Reaction of Some Indole Ketones with Iodine and Pyridine.
Hart G and Potts KT.
The Journal of Organic Chemistry, 27(8), 2940-2942 (1962)
Desulfurization of Thiiranes with Iodine.
Helmkamp GK and Pettitt DJ.
The Journal of Organic Chemistry, 27(80, 2942-2943 (1962)
Mitra Shokrollahi et al.
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society, 31(10), e13598-e13598 (2019-04-24)
Activating luminal 5-HT4 receptors results in the release of 5-HT from enterochromaffin cells into the lamina propria to modulate colonic motility. Our aim was to evaluate characteristics of colonic motor patterns involved in the prokinetic effects of intraluminal prucalopride in
Yuan Guo et al.
Neuropsychobiology, 80(1), 52-63 (2020-07-15)
The 5-hydroxytryptamine (5-HT) neurotransmitter system and lateral habenula (LHb) are involved in the regulation of depression, while the mechanisms remain to be clarified. The effects and possible mecha-nism underlying activation or blockade of 5-HT4 receptors (5-HT4Rs) in the LHb in
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