465178
2,2′-(1,2-乙二基双氧代)双乙硫醇
95%
别名:
1,2-双(2-乙氧基硫醇)乙烷, 3,6-二氧-1,8-辛二硫醇
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关于此项目
线性分子式:
HSCH2CH2OCH2CH2OCH2CH2SH
化学文摘社编号:
分子量:
182.30
UNSPSC Code:
12352103
NACRES:
NA.23
PubChem Substance ID:
EC Number:
239-044-2
Beilstein/REAXYS Number:
1901671
MDL number:
InChI key
HCZMHWVFVZAHCR-UHFFFAOYSA-N
InChI
1S/C6H14O2S2/c9-5-3-7-1-2-8-4-6-10/h9-10H,1-6H2
SMILES string
SCCOCCOCCS
assay
95%
refractive index
n20/D 1.509 (lit.)
bp
225 °C (lit.)
density
1.12 g/mL at 25 °C (lit.)
Quality Level
General description
3,6-二氧杂-1,8-辛二硫醇不具有挥发性。
Application
在研究中使用3,6-二氧杂-1,8-辛二硫醇（DODT）对肽进行切割，以建立治疗慢性恰加斯病的合成肽血清学方法。DODT可用于在基于Fmoc的肽合成中，对非恶臭清除剂进行开发。
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Oral - Acute Tox. 4 Inhalation - Aquatic Acute 1 - Aquatic Chronic 1
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 2
flash_point_f
285.8 °F
flash_point_c
141 °C
ppe
Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
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Zhang J, et al.
Royal Society of Chemistry Advances, 6(14), 11848-11854 (2016)
Andrea D'Ambrogio et al.
Nucleic acids research, 37(12), 4116-4126 (2009-05-12)
Nuclear factor TDP-43 has been reported to play multiple roles in transcription, pre-mRNA splicing, mRNA stability and mRNA transport. From a structural point of view, TDP-43 is a member of the hnRNP protein family whose structure includes two RRM domains
Insights into the effect of surface ligands on the optical properties of thiolated Au 25 nanoclusters.
Yuan X, et al.
Chemical Communications (Cambridge, England), 52(30), 5234-5237 (2016)
A Teixeira et al.
Protein and peptide letters, 9(5), 379-385 (2002-10-09)
We have synthesized a random group of peptides and performed cleavages using various cleavage cocktails including 3,6-dioxa-1,8-octanedithiol (DODT). Purity of the peptides was compared to that obtained with standard protocols for cleavage using RP-HPLC and Maldi-Tof mass spectrometry. We show
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