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463442

Sigma-Aldrich

4-[2-(5-氯-2-甲氧基苯甲酰氨基)乙基]苯磺酰胺

95%

别名:

4-[2-(5-Chloro-2-methoxybenzamido)ethyl]phenylsulfonamide

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About This Item

线性分子式:
ClC6H3(OCH3)CONHCH2C6H4SO2NH2
CAS号:
16673-34-0
分子量:
368.84
EC 号:
240-722-5
MDL编号:
MFCD00193756
UNSPSC代码:
12352100
PubChem化学物质编号:
24870067
NACRES:
NA.22

质量水平

100

方案

95%

mp

209-214 °C (lit.)

官能团

amide
chloro

SMILES字符串

COc1ccc(Cl)cc1C(=O)NCCc2ccc(cc2)S(N)(=O)=O

InChI

1S/C16H17ClN2O4S/c1-23-15-7-4-12(17)10-14(15)16(20)19-9-8-11-2-5-13(6-3-11)24(18,21)22/h2-7,10H,8-9H2,1H3,(H,19,20)(H2,18,21,22)

InChI key

KVWWTCSJLGHLRM-UHFFFAOYSA-N

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相关类别

一般描述

5-Chloro-2-methoxy-N-[2-(4-sulfamoylphenyl)ethyl]benzamide is an organic building block. It has been reported as an intermediate in the synthesis of glyburide. Synthesis of 5-chloro-2-methoxy-N-[2-(4-sulfamoylphenyl)ethyl]benzamide has been reported.

储存分类代码

11 - Combustible Solids

WGK

WGK 1

闪点(°F)

Not applicable

闪点(°C)

Not applicable

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分析证书(COA)

Lot/Batch Number
18530LQ

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Molecular regulation of cell fate in cerebral ischemia: role of the inflammasome and connected pathways
Trendelenburg G.
Journal of Cerebral Blood Flow and Metabolism (2014)
Carlo Marchetti et al.
Journal of cardiovascular pharmacology, 63(4), 316-322 (2013-12-18)
The formation of the NLRP3 inflammasome in the heart during acute myocardial infarction amplifies the inflammatory response and mediates further damage. Glyburide has NLRP3 inhibitory activity in vitro but requires very high doses in vivo, associated with hypoglycemia. The aim
Reply to Letter Regarding Article," NLRP3 Inflammasome as a Therapeutic Target in Myocardial Infarction.
Takahashi M.
International Heart Journal, 55(4), 380-380 (2014)

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