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Merck
CN

460923

Sigma-Aldrich

炔丙基氯甲酸酯

96%

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别名:
(Prop-2-ynyloxy)carbonyl chloride, 2-Propyn-1-yl carbonochloridate, 2-Propynyl chloroformate, Prop-2-yn-1-yl carbonochloridate, Propargyloxycarbonyl chloride
线性分子式:
HC≡CCH2OCOCl
CAS号:
分子量:
118.52
Beilstein:
1745399
MDL编号:
UNSPSC代码:
12352100
PubChem化学物质编号:
NACRES:
NA.22

蒸汽压

0.65 psi ( 20 °C)

质量水平

检测方案

96%

反应适用性

reaction type: click chemistry

折射率

n20/D 1.435 (lit.)

bp

118-122 °C (lit.)

密度

1.215 g/mL at 25 °C (lit.)

储存温度

2-8°C

SMILES字符串

ClC(=O)OCC#C

InChI

1S/C4H3ClO2/c1-2-3-7-4(5)6/h1H,3H2

InChI key

RAMTXCRMKBFPRG-UHFFFAOYSA-N

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一般描述

氯甲酸炔丙酯是一种炔丙基酯。它是羟基和氨基的保护基团。本文用扩展的 Grunwald-Winstein 方程分析了氯甲酸炔丙酯在各种不同亲核能力和电离功率的溶剂中的溶剂分解速率。

应用

氯甲酸炔丙酯可用于制备以下物质:
  • 联萘酚二乙炔衍生物
  • 丙炔五氟苯基碳酸酯
  • N -Poc 保护的氨基酸(Poc = 炔丙基氧羰基)

警示用语:

Danger

危险分类

Acute Tox. 4 Oral - Flam. Liq. 3 - Skin Corr. 1B

WGK

WGK 3

闪点(°F)

closed cup

闪点(°C)

closed cup

个人防护装备

Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter

法规信息

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Synthesis and applications of propargyl pentafluorophenyl carbonate for peptide synthesis.
Bhat RG, et al.
Tetrahedron Letters, 43(13), 2467-2469 (2002)
Propargyloxycarbonyl (Poc) amino acid chlorides as efficient coupling reagents for the synthesis of 100% diastereopure peptides and resin bound tetrathiomolybdate as an effective deblocking agent for the Poc group.
Bhat RG, et al.
Chemical Communications (Cambridge, England), 8, 812-813 (2002)
Organogold (I) complexes of a C 2-symmetric diacetylide ligand derived from 1, 1'-bi-2-naphthol.
Burchell TJ, et al.
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Propargyloxycarbonyl and propargyl groups for novel protection of amino, hydroxy, and carboxy functions.
Fukase Y, et al.
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