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452483

Sigma-Aldrich

1-甲基---色氨酸

95%, for peptide synthesis

别名:

(2R)-2-Amino-3-(1-methyl-1H-indol-3-yl)propanoic acid, D-(+)-1-Methyltryptophan

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About This Item

经验公式（希尔记法）:
C12H14N2O2
CAS号:
110117-83-4
分子量:
218.25
MDL编号:
MFCD00274271
UNSPSC代码:
12352209
PubChem化学物质编号:
24868706
NACRES:
NA.22

product name

1-甲基---色氨酸, 95%

质量水平

100

检测方案

95%

形式

lumps and powder

旋光性

[α]22/D +12.4°, c = 2 in acetic acid

反应适用性

reaction type: solution phase peptide synthesis

mp

242-245 °C (lit.)

应用

peptide synthesis

SMILES字符串

Cn1cc(C[C@@H](N)C(O)=O)c2ccccc12

InChI

1S/C12H14N2O2/c1-14-7-8(6-10(13)12(15)16)9-4-2-3-5-11(9)14/h2-5,7,10H,6,13H2,1H3,(H,15,16)/t10-/m1/s1

InChI key

ZADWXFSZEAPBJS-SNVBAGLBSA-N

相关类别

应用

用于通过色氨酸酯与醛的 Pictet-Spengler 反应，制备多种天然产物，包括大灵碱生物碱，也可用于合成 1-取代 indolactam 前体。

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

分析证书(COA)

输入产品批号来搜索 分析证书(COA) 。批号可以在产品标签上"批“ （Lot或Batch）字后找到。

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  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  2. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  3. What is Product 452483, 1-Methyl-D-tryptophan, soluble in?

    While we don't test the solubility of this product directly, we do have to dissolve it in acetic acid in order to test the optical rotation. We would also expect this to be soluble in a dilute hydrochloric acid solution (50mg/mL in 5N HCl). Both heat and sonication may be required in order to prepare a homogenous solution. Also, based on our experience with the DL (Product No. 860646) and L (Product No. 447439) forms, we would expect that dilute sodium hydroxide would also be a potential solvent (1g/100mL of 1M NaOH).

  4. What is the solution stability of Product 452483, 1-Methyl-D-tryptophan?

    Unfortunately, we do not perform solution stability testing on this item or have experience with storing tryptophan solutions, so we would recommend making a fresh batch with each use.

  5. How should Product 452483, 1-Methyl-D-tryptophan, be stored?

    This material is stable at room temperature without any special handling precautions.

  6. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  7. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  8. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

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Zhidan Tu et al.
Stem cells and development, 19(11), 1803-1809 (2010-02-19)
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Cook, J.M. et al.
Heterocycles, 27, 2795-2795 (1988)
Irie, K. et al.
Tetrahedron, 51, 6255-6255 (1995)
Shoba Amarnath et al.
PLoS biology, 8(2), e1000302-e1000302 (2010-02-04)
Immunotherapy using regulatory T cells (Treg) has been proposed, yet cellular and molecular mechanisms of human Tregs remain incompletely characterized. Here, we demonstrate that human Tregs promote the generation of myeloid dendritic cells (DC) with reduced capacity to stimulate effector
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