所有图片(2)
About This Item
线性分子式:
CH2[P(O)Cl2]2
CAS号:
分子量:
249.78
MDL编号:
UNSPSC代码:
12352100
PubChem化学物质编号:
NACRES:
NA.22
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质量水平
方案
97%
表单
solid
mp
102-104 °C (lit.)
官能团
phosphine oxide
SMILES字符串
ClP(Cl)(=O)CP(Cl)(Cl)=O
InChI
1S/CH2Cl4O2P2/c2-8(3,6)1-9(4,5)7/h1H2
InChI key
VRXYCDTWIOCJBH-UHFFFAOYSA-N
一般描述
亚甲基双氯化磷是一种有机磷化合物，常用于膦酰化反应。相比POCl3，反应性更强，反应速率更快。这是由于CH2基的作用(lack of electron back-donation)，造成磷原子中心的亲电性更强。
应用
亚甲基双（二氯膦酸）可用于以下研究：
- 麦考酚亚甲基双（膦酸）衍生物的合成。
- 核苷的膦酰化。
- P,P′-亚甲基双膦酸部分酯化物的制备。
- 亚甲基双膦酸对称双酯和对称四酯的合成。
警示用语：
Danger
危险声明
危险分类
Eye Dam. 1 - Skin Corr. 1B
补充剂危害
储存分类代码
8A - Combustible corrosive hazardous materials
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
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As therapeutic agents of choice in the treatment of complicated infections, glycopeptide antibiotics are often preferentially used in cases of osteomyelitis, an infection located in bone and notoriously difficult to successfully manage. Yet frequent and heavy doses of these systemically
A direct method for the synthesis of nucleoside 5'-methylenebis (phosphonate) s from nucleosides.
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Tetrahedron Letters, 46(!4), 2417-2421 (2005)
Facile high yielding synthesis of symmetric esters of methylenebisphosphonic acid.
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