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About This Item
经验公式（希尔记法）:
C7H11NO4
CAS号:
分子量:
173.17
Beilstein:
84043
EC 号:
MDL编号:
UNSPSC代码:
12352209
eCl@ss:
32160406
PubChem化学物质编号:
NACRES:
NA.22
product name
反式-1-乙酰基-4-羟基-L-脯氨酸, ≥98%
质量水平
检测方案
≥98%
形式
powder
旋光性
[α]20/D −119°, c = 4 in H2O
反应适用性
reaction type: solution phase peptide synthesis
mp
132-133 °C (dec.) (lit.)
应用
peptide synthesis
SMILES字符串
CC(=O)N1C[C@H](O)C[C@H]1C(O)=O
InChI
1S/C7H11NO4/c1-4(9)8-3-5(10)2-6(8)7(11)12/h5-6,10H,2-3H2,1H3,(H,11,12)/t5-,6+/m1/s1
InChI key
BAPRUDZDYCKSOQ-RITPCOANSA-N
相关类别
应用
反式-1-乙酰基-4-羟基-L-脯氨酸可用于：
- 4-氟谷氨酸的立体定向合成。
- 合成希佩尔-林道综（VHL）E3泛素连接酶的分子靶点。
- 作为合成假聚（氨基酸）的前体，例如聚（反式-4-羟基-4-酰基-L-脯氨酸酯）和可生物降解的聚合物聚（乳酸-乙醇酸-4-羟脯氨酸）。
警示用语：
Danger
危险声明
危险分类
Eye Dam. 1
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
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Synthesis and characterization of a novel biodegradable polymer poly (lactic acid?glycolic acid?4?hydroxyproline).
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Structure-guided design and optimization of small molecules targeting the protein?protein interaction between the von Hippel?Lindau (VHL) E3 ubiquitin ligase and the hypoxia inducible factor (HIF) alpha subunit with in vitro nanomolar affinities.
Galdeano C, et al.
Journal of Medicinal Chemistry, 57(20), 8657-8663 (2014)
[Action of N-acetyl-hydroxyproline in the treatment of cutaneous ulcerative lesions].
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H Riera et al.
Revue du rhumatisme et des maladies osteo-articulaires, 57(7-8), 579-583 (1990-07-01)
The authors have studied in organ culture, the effects of oxaceprol-structural analogue of hydroxyproline, on the proteoglycan and protein synthesis and degradation by calf articular chondrocytes. A stimulation of the incorporation of 35SO4, which indicate proteoglycan synthesis, was shown. The
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