质量水平
检测方案
97%
形式
liquid
折射率
n20/D 1.48 (lit.)
bp
123-124 °C (lit.)
密度
1.326 g/mL at 25 °C (lit.)
SMILES字符串
BrCC1CCC1
InChI
1S/C5H9Br/c6-4-5-2-1-3-5/h5H,1-4H2
InChI key
FLHFTXCMKFVKRP-UHFFFAOYSA-N
一般描述
(Bromomethyl)cyclobutane (bromomethyl-cyclobutane) is an aryl fluorinated building block. Its reaction with various hydroxychromen-4-one derivatives in the presence of anhydrous K2CO3/dry acetone and Bu4N+I- (PTC) has been investigated.
应用
用于 10-酮吗啡喃类似物的合成,以及他们与三种阿片受体结合的研究。
警示用语:
Warning
危险声明
危险分类
Flam. Liq. 3
WGK
WGK 2
个人防护装备
Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
法规信息
新产品
Cyclopropylmethyl-and cyclobutylmethyllithium by an arene-catalyzed lithiation. Stability and reactivity.
Tetrahedron, 66(16), 2928-2935 (2010)
Journal of medicinal chemistry, 47(1), 165-174 (2003-12-30)
A series of 10-ketomorphinan analogues were synthesized, and their binding affinity at all three opioid receptors was investigated. In most cases, high affinity at micro and kappa receptors, and lower affinity at delta receptor was observed, resulting in good selectivity
Photochemical synthesis and antimicrobial studies of new chromen-4-one based vinyl ethers.
Arabian Journal of Chemistry (2013)
Journal of medicinal chemistry, 53(1), 402-418 (2009-11-26)
The phenolic group of the potent mu and kappa opioid morphinan agonist/antagonists cyclorphan and butorphan was replaced by phenylamino and benzylamino groups including compounds with para-substituents in the benzene ring. These compounds are highly potent mu and kappa ligands, e.g.
Journal of medicinal chemistry, 52(19), 6163-6167 (2009-09-15)
The natural proteasome inhibitor salinosporamide A from the marine bacterium Salinispora tropica is a promising drug candidate for the treatment of multiple myeloma and mantle cell lymphoma. Using a comprehensive approach that combined chemical synthesis with metabolic engineering, we generated
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