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Merck
CN

441171

Sigma-Aldrich

(溴甲基)环丁烷

97%

别名:

环丁基甲基溴

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About This Item

线性分子式:
C4H7CH2Br
CAS号:
分子量:
149.03
MDL编号:
UNSPSC代码:
12352100
PubChem化学物质编号:
NACRES:
NA.22

质量水平

检测方案

97%

形式

liquid

折射率

n20/D 1.48 (lit.)

bp

123-124 °C (lit.)

密度

1.326 g/mL at 25 °C (lit.)

SMILES字符串

BrCC1CCC1

InChI

1S/C5H9Br/c6-4-5-2-1-3-5/h5H,1-4H2

InChI key

FLHFTXCMKFVKRP-UHFFFAOYSA-N

一般描述

(Bromomethyl)cyclobutane (bromomethyl-cyclobutane) is an aryl fluorinated building block. Its reaction with various hydroxychromen-4-one derivatives in the presence of anhydrous K2CO3/dry acetone and Bu4N+I- (PTC) has been investigated.

应用

用于 10-酮吗啡喃类似物的合成,以及他们与三种阿片受体结合的研究。

象形图

Flame

警示用语:

Warning

危险声明

危险分类

Flam. Liq. 3

WGK

WGK 2

个人防护装备

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

法规信息

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Pe?afiel I, et al.
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Journal of medicinal chemistry, 47(1), 165-174 (2003-12-30)
A series of 10-ketomorphinan analogues were synthesized, and their binding affinity at all three opioid receptors was investigated. In most cases, high affinity at micro and kappa receptors, and lower affinity at delta receptor was observed, resulting in good selectivity
Photochemical synthesis and antimicrobial studies of new chromen-4-one based vinyl ethers.
Yusuf M, et al.
Arabian Journal of Chemistry (2013)
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Journal of medicinal chemistry, 53(1), 402-418 (2009-11-26)
The phenolic group of the potent mu and kappa opioid morphinan agonist/antagonists cyclorphan and butorphan was replaced by phenylamino and benzylamino groups including compounds with para-substituents in the benzene ring. These compounds are highly potent mu and kappa ligands, e.g.
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Journal of medicinal chemistry, 52(19), 6163-6167 (2009-09-15)
The natural proteasome inhibitor salinosporamide A from the marine bacterium Salinispora tropica is a promising drug candidate for the treatment of multiple myeloma and mantle cell lymphoma. Using a comprehensive approach that combined chemical synthesis with metabolic engineering, we generated

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