质量水平
检测方案
99%
形式
powder
光学纯度
ee: 99% (GLC)
mp
118-121 °C (lit.)
SMILES字符串
N[C@@H]1[C@H](O)Cc2ccccc12
InChI
1S/C9H11NO/c10-9-7-4-2-1-3-6(7)5-8(9)11/h1-4,8-9,11H,5,10H2/t8-,9+/m1/s1
InChI key
LOPKSXMQWBYUOI-BDAKNGLRSA-N
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一般描述
1S,2R)-(-)-顺式-1-氨基-2-茚满醇是茚地那韦的一种主要成分,而茚地那韦是一种有效的HIV(人类免疫缺陷病毒)蛋白酶抑制剂。
应用
1S,2R)-(-)-顺式-1-氨基-2-茚满醇可被用于制备:
- 通过与(E,E)-4-氧代-2-[((2,6,6-三甲基环己-1-烯基)乙烯基]丁-2-烯酸酯反应制备(-)-1,2,5,6-四氢吡啶。
- 可催化具有高对映选择性芳族酮的不对称还原的恶唑硼烷催化剂。
- (RS,1S,2R)-(-)-2,4,6-三甲基苯磺酸1-(2,4,6-三甲基苯磺酰基氨基)茚满-2-基酯.
在纤溶酶II抑制的研究中用于制备基于甘露醇基的支架。 天冬氨酸蛋白酶如纤溶酶I和II是抗疟疾的新型潜在靶标。
物理属性
可用于不对称合成的手性配体。
法律信息
经Sterling Pharma Solutions Limited授权进行销售。
警示用语:
Warning
危险声明
危险分类
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
Highly stereoselective asymmetric 6p-azaelectrocyclization utilizing the novel 7-alkyl substituted cis-1-amino-2-indanols: Formal synthesis of 20-epiuleine.
Journal of the American Chemical Society, 124(33), 9660-9661 (2002)
Cis-1-amino-2-indanol in asymmetric synthesis. Part I. A practical catalyst system for the enantioselective borane reduction of aromatic ketones.
Tetrahedron Letters, 35(36), 6631-6634 (1994)
Aldrichimica Acta, 31, 3-3 (1998)
Improved asymmetric synthesis of aziridine 2-phosphonates using (S)-(+)-2, 4, 6-trimethylphenylsulfinamide.
The Journal of Organic Chemistry, 68(18), 6894-6898 (2003)
Bioorganic & medicinal chemistry, 11(17), 3723-3733 (2003-08-07)
A series of C(2)-symmetric compounds with a mannitol-based scaffold has been investigated, both theoretically and experimentally, as Plm II inhibitors. Four different stereoisomers with either benzyloxy or allyloxy P1/P1' side chains were studied. Computational ranking of the binding affinities of
Chromatograms
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