所有图片(2)
About This Item
线性分子式:
H2NC6H3(Cl)OH
CAS号:
分子量:
143.57
MDL编号:
UNSPSC代码:
12352100
PubChem化学物质编号:
NACRES:
NA.22
质量水平
检测方案
98%
mp
150-153 °C (lit.)
SMILES字符串
Nc1ccc(O)c(Cl)c1
InChI
1S/C6H6ClNO/c7-5-3-4(8)1-2-6(5)9/h1-3,9H,8H2
InChI key
ZYZQSCWSPFLAFM-UHFFFAOYSA-N
一般描述
4-Amino-2-chlorophenol (4A2CP) is a chlorinated aniline. Nephrotoxic potential of 4-amino-2-chlorophenol and its comparison with 4-aminophenol, 4-amino-2-chlorophenol, 4-amino-3-chlorophenol and 4-amino-2,6-dichlorophenol using isolated renal cortical cells from male Fischer 344 rats has been investigated.
应用
4-Amino-2-chlorophenol may be used in the synthesis of the following compounds:
- N-(3-chloro-4-hydroxyphenyl)-N′,N′-dimethylurea
- 1,4-diketo-3-((4-[N-(3-chloro-4-hydroxyphenyl)amino]sulfonyl)phenyl)-6-phenylpyrrolo[3,4-c]pyrrole, a novel fluorescent pH-indicator
- 4-(4-aminophenoxy)-N-(4-(4-aminophenoxy) benzylidene)-3-chloroaniline
- 4-(4-amino-3-methylphenoxy)-N-(4-(4-amino-3-methylphenoxy)benzylidene)-3-chloroaniline
- 4-(4-amino-2-methylphenoxy)-N-(4-(4-amino-2-methylphenoxy)benzylidene)-3-chloroaniline
警示用语：
Warning
危险分类
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
Fluorescent materials for pH sensing and imaging based on novel 1,4-diketopyrrolo-[3,4-c] pyrrole dyes.
Aigner D, et al.
Journal of Material Chemistry C, 1(36), 5685-5693 (2013)
Gary O Rankin et al.
Chemico-biological interactions, 222, 126-132 (2014-12-03)
Chlorinated anilines are nephrotoxicants both in vivo and in vitro. The mechanism of chloroaniline nephrotoxicity may occur via more than one mechanism, but aminochlorophenol metabolites appear to contribute to the adverse in vivo effects. The purpose of this study was
S K Hong et al.
Toxicology, 110(1-3), 47-58 (1996-06-17)
Aminophenols and halogenated anilines induce nephrotoxicity and mild hepatotoxicity in rats. In this study, the in vivo and in vitro nephrotoxic potential of 4-amino-2-chlorophenol and 2-amino-4-chlorophenol, monochlorinated aminophenols and potential metabolites of 3-chloroaniline, was evaluated. Hepatotoxicity of both compounds was
C Tixier et al.
Environmental toxicology and chemistry, 20(7), 1381-1389 (2001-07-04)
The degradation products of diuron (photoproducts and metabolites), already described in the literature, were synthesized in order to carry out further investigations. Their ecotoxicity was determined using the standardized Microtox test, and most of the derivatives presented a nontarget toxicity
Synthesis and Characterization of Novel Processable and Flexible Polyimides Containing 3, 6-Di(4-carboxyphenyl) pyromellitic Dianhydride.
Khosa MK, et al.
Advances in Chemistry, 2014 (2014)
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