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质量水平
检测方案
97%
形式
solid
mp
127-130 °C (lit.)
溶解性
DMF: soluble(lit.)
dichloromethane: soluble(lit.)
SMILES字符串
OC(=O)c1ccc(CBr)c(c1)[N+]([O-])=O
InChI
1S/C8H6BrNO4/c9-4-6-2-1-5(8(11)12)3-7(6)10(13)14/h1-3H,4H2,(H,11,12)
InChI key
QMAHVAFURJBOFV-UHFFFAOYSA-N
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一般描述
4-Bromomethyl-3-nitrobenzoic acid (BNBA) is a benzoic acid derivative. It has been synthesized by the nitration of 4-bromomethylbenzoic acid using fuming nitric acid. It participates in the synthesis of 3,4-dihydro-2(1H)-quinazolinones and 3,4-dihydro-1H-quinazolin-2-thiones.
应用
4-Bromomethyl-3-nitrobenzoic acid may be used in the following studies:
- As a reactant in the synthesis of 4-bromomethyl-3-nitrobenzoic acid succinimide ester (BNBA-SE).
- As a reactant in the synthesis of 4-(2-hydroxyethylmercaptylmethyl)-3-nitrobenzoic acid.
- As a reactant in the synthesis of decyl 4-(bromomethyl)-3-nitrobenzoate.
- As a reactant in the synthesis of 4-((2-(hydroxymethyl)phenylamino)methyl)-3-nitrobenzoic acid.
- As a thiol photo-deprotection reagent.
- As a UV-cleavable reagent to functionalize polyacrylamide acryl hydrate (PAAH).
- As a photocleavable linker to form localized photoinversion of surface charges inside the colloidal crystal.
- As a starting material in the synthesis of 2H-indazole based library using parallel solution-phase methods.
- As a reactant in the synthesis of (N-allyloxycarbonyl)-5-aminopent-1-yl 4-bromomethyl-3-nitrobenzoate.
警示用语:
Danger
危险声明
危险分类
Skin Corr. 1B
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
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This work describes how selective patterning of hydrophobic and hydrophilic areas inside microchannels of microfluidic devices can be achieved by combining well-known chemical protocols and standard photolithography equipment (365 nm). Two techniques have been performed and compared. The first technique
Molecular diversity, 16(2), 241-249 (2011-12-20)
An efficient microwave-assisted and water-soluble ionic liquid (IL)-supported synthesis of medicinally important dihydro- and tetrahydroquinazolines has been developed. The protocol involves the S(N)2 substitution reaction of IL-bound 4-bromomethyl-3-nitrobenzoic acid with various primary amines to provide IL-bound 4-((alkylamino) methyl)-3-nitrobenzoate under microwave
Solid-phase synthesis of 3, 4-dihydro-2 (1H)-quinazolinones and 3, 4-dihydro-1H-quinazolin-2-thiones.
Tetrahedron Letters, 42(25), 4119-4121 (2001)
Syntheses of nucleosides designed for combinatorial DNA sequencing.
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