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About This Item
经验公式（希尔记法）:
C5H12N2
CAS号:
分子量:
100.16
MDL编号:
UNSPSC代码:
12352005
PubChem化学物质编号:
NACRES:
NA.22
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质量水平
方案
97%
表单
liquid
旋光性
[α]20/D +20°, c = 1 in chloroform
折射率
n20/D 1.482 (lit.)
沸点
65 °C/11 mmHg (lit.)
密度
0.933 g/mL at 25 °C (lit.)
官能团
amine
SMILES字符串
NC[C@@H]1CCCN1
InChI
1S/C5H12N2/c6-4-5-2-1-3-7-5/h5,7H,1-4,6H2/t5-/m0/s1
InChI key
AUKXFNABVHIUAC-YFKPBYRVSA-N
一般描述
(S)-(+)-2-(Aminomethyl)pyrrolidine is a chiral vicinal diamine.
应用
用于合成具有抗癌活性的化合物。
(S)-(+)-2-(Aminomethyl)pyrrolidine can be used as an organocatalyst:
It can also be used as a reactant to prepare Schiff base metal complexes with pyrrolidine fragment as a ligand in asymmetric synthesis.
- For the asymmetric transformation of (S)-alanine.
- In the asymmetric α-fluorination of linear and branched aldehydes using N-fluorobenzenesulfonamide as the fluorinating agent.
It can also be used as a reactant to prepare Schiff base metal complexes with pyrrolidine fragment as a ligand in asymmetric synthesis.
警示用语：
Warning
危险分类
Eye Irrit. 2 - Flam. Liq. 3 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
储存分类代码
3 - Flammable liquids
WGK
WGK 3
闪点(°F)
116.6 °F - closed cup
闪点(°C)
47 °C - closed cup
个人防护装备
Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
法规信息
危险化学品
Direct asymmetric α-fluorination of aldehydes
Steiner DD, et al.
Angewandte Chemie (International ed. in English), 44(24), 3706-3710 (2005)
Asymmetric Transformation of Alanine via Optically Labile Imidazolines
Shibata S, et al.
Bulletin of the Chemical Society of Japan, 52(10), 2938-2941 (1979)
Dioxovanadium (V) complexes of Schiff bases derived from S-(+)-2-(aminomethyl) pyrrolidine and aromatic o-hydroxycarbonyl compounds: Synthesis, characterization and structure
Kwiatkowski E, et al.
Polyhedron, 25(15), 2809-2814 (2006)
K Morikawa et al.
Journal of pharmaceutical sciences, 80(9), 837-842 (1991-09-01)
The optical isomers of 2-aminomethylpyrrolidine(1,1-cyclobutane- dicarboxylato)platinum(II) (DWA2114, 1), which has potent antitumor activity against various tumors, were synthesized. They were examined for antitumor activity against Colon 26 carcinoma in a sc-iv system, and changes in urinary protein and sugar levels
商品
Chiral vicinal diamines are of tremendous interest to the synthetic chemist as they are found in many chiral catalysts and pharmaceuticals.
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