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线性分子式:
HOOCCH2CH(NH2)CONHCH(CH2C6H5)CO2H
化学文摘社编号:
分子量:
280.28
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352209
EC Number:
236-557-3
MDL number:
Beilstein/REAXYS Number:
2817528
产品名称
天冬氨酰-苯丙氨酸, 96%
InChI key
YZQCXOFQZKCETR-UWVGGRQHSA-N
InChI
1S/C13H16N2O5/c14-9(7-11(16)17)12(18)15-10(13(19)20)6-8-4-2-1-3-5-8/h1-5,9-10H,6-7,14H2,(H,15,18)(H,16,17)(H,19,20)/t9-,10-/m0/s1
SMILES string
N[C@@H](CC(O)=O)C(=O)N[C@@H](Cc1ccccc1)C(O)=O
assay
96%
form
powder
optical activity
[α]20/D +12.5°, c = 1 in 0.5 M HCl
reaction suitability
reaction type: solution phase peptide synthesis
mp
236-239 °C (lit.)
application(s)
peptide synthesis
Quality Level
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Packaging
无底玻璃瓶。内含物在插入的融合锥体内。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
S S Leung et al.
Journal of pharmaceutical sciences, 86(1), 64-71 (1997-01-01)
Some solid-state pharmaceutical properties and the solid-state thermal stability of the model dipeptides aspartame (APM) and aspartylphenylalanine (AP), have been investigated. Studies by differential scanning calorimetry (DSC), thermal gravimetric analysis (TGA), high-performance liquid chromatography, powder X-ray diffraction, and optical microscopy
E G Burton et al.
The Journal of nutrition, 119(5), 713-721 (1989-05-01)
A new beta-aspartyl dipeptide, N-beta-L-aspartyl-L-phenylalanine (beta-AP), has been isolated and identified in urine and plasma from normal human volunteers. beta-AP was isolated from urine samples by high performance liquid chromatography (HPLC). Its identity and stereochemistry were demonstrated by HPLC and
N A Tobey et al.
Gastroenterology, 91(4), 931-937 (1986-10-01)
Aspartame [Nutrasweet, Equal (Searle Consumer Products, Chicago, Ill.)] is the methyl ester of the dipeptide aspartylphenylalanine (Asp-Phe). After hydrolysis of the ester bond in the intestinal lumen, the dipeptide is apparently absorbed and digested in the same manner as dipeptides
E A Timokhina et al.
Prikladnaia biokhimiia i mikrobiologiia, 23(3), 426-428 (1987-05-01)
A technique for quantitative determining of the synthetic sweetener aspartame. NH2-Asp-Phe-OMe and its hydrolysis product, NH2-Asp-Phe-OH, is proposed based on the use of an amino acid analyzer.
W E Lipton et al.
Metabolism: clinical and experimental, 40(12), 1337-1345 (1991-12-01)
The dipeptide sweetener aspartame (N-L-alpha-aspartyl-L-phenylalanine, 1-methyl ester; alpha-APM) is relatively stable in dry powder form. However, when exposed to elevated temperature, extremes of pH and/or moisture, alpha-APM is converted into a variety of products. In aqueous solution alpha-APM decomposes to
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