419648
2,5-二叔丁基-1,4-苯醌
99%
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线性分子式:
[(CH3)3C]2C6H2(=O)2
化学文摘社编号:
分子量:
220.31
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352100
EC Number:
219-552-0
MDL number:
Assay:
99%
InChI key
ZZYASVWWDLJXIM-UHFFFAOYSA-N
InChI
1S/C14H20O2/c1-13(2,3)9-7-12(16)10(8-11(9)15)14(4,5)6/h7-8H,1-6H3
SMILES string
CC(C)(C)C1=CC(=O)C(=CC1=O)C(C)(C)C
assay
99%
mp
152-154 °C (lit.)
functional group
ketone
Quality Level
General description
2,5-二叔丁基-1,4-苯醌（DTBBQ）是一种2,5-二取代醌。它是一种从海洋链霉菌Streptomyces sp. VITVSK1中分离出来的抗菌化合物。 已有研究使用高压EPR技术，评估了2,5-二叔丁基-1,4-苯醌离子对中Na+和K+的分子内和分子间迁移速率的压力依赖性。
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
A Lückhoff et al.
Biophysical journal, 67(1), 177-182 (1994-07-01)
Depletion of intracellular calcium stores induces transmembrane Ca2+ influx. We studied Ca(2+)- and Ba(2+)-permeable ion channels in A431 cells after store depletion by dialysis of the cytosol with 10 mM BAPTA solution. Cell-attached patches of cells held at low (0.5
R J Dolor et al.
The American journal of physiology, 262(1 Pt 1), C171-C181 (1992-01-01)
We have investigated the role of the intracellular Ca2+ pool in regulating Ca2+ entry into vascular endothelial cells. The intracellular Ca2+ pool was mobilized using either thapsigargin (TG) or 2',5'-di(tert-butyl)-1,4-benzohydroquinone (BHQ), inhibitors of the endoplasmic reticulum Ca(2+)-adenosinetriphosphatase (ATPase). Mobilization of
Y K Ju et al.
The Journal of physiology, 525 Pt 3, 695-705 (2000-06-16)
The mechanisms of sarcoplasmic reticulum (SR) Ca2+ release in pacemaker cells from the sinus venosus of the cane toad (Bufo marinus) were studied. Single, isolated cells were voltage clamped using a nystatin-perforated patch. Ionic currents and intracellular Ca2+ concentration ([Ca2+]i)
L Missiaen et al.
European journal of pharmacology, 227(4), 391-394 (1992-12-01)
Specific inhibitors of the endoplasmic-reticulum Ca2+ pump will deplete intracellular stores and are therefore useful to study the role of store depletion on plasma-membrane Ca2+ permeability. We now report that the Ca(2+)-pump inhibitor 2,5-di-(tert-butyl)-1,4-benzohydroquinone (tBuBHQ) reduces the passive Ca2+ leak
Vinay Gopal Jannu et al.
International journal of bioinformatics research and applications, 11(2), 142-152 (2015-03-20)
The incidence of bacterial disease has increased tremendously in the last decade, because of the emergence of drug resistance strains within the bacterial pathogens. The present study was to investigate the antibacterial compound 2,5-di-tert-butyl-1,4-benzoquinone (DTBBQ) isolated from marine Streptomyces sp.
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