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Merck
CN

415936

Sigma-Aldrich

3,4-二氢-2(1H)-喹啉酮

98%

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别名:
氢化喹诺酮
经验公式(希尔记法):
C9H9NO
CAS号:
分子量:
147.17
MDL编号:
UNSPSC代码:
12352100
PubChem化学物质编号:
NACRES:
NA.22

检测方案

98%

mp

165-167 °C (lit.)

SMILES字符串

O=C1CCc2ccccc2N1

InChI

1S/C9H9NO/c11-9-6-5-7-3-1-2-4-8(7)10-9/h1-4H,5-6H2,(H,10,11)

InChI key

TZOYXRMEFDYWDQ-UHFFFAOYSA-N

一般描述

合成了一系列具有 sigma-1 受体(σ1R)拮抗剂活性的 3,4-二氢-2(1H)-喹啉酮衍生物。使用N-(1′-烷氧基)环丙基-2-卤代苯胺作为起始试剂合成了 3,4-二氢-2((1)H)-喹啉酮。在钯催化剂的存在下环丙烷环的扩环反应是合成的主要步骤。通过在固相上重排 β-内酰胺中间体合成了 3,4-二氢-2(1H)-喹啉酮的文库

应用

在富集培养实验中,可以将 3,4-二氢-2(1H)-喹啉酮用作在假单胞菌培养基中的培养基补充剂。

象形图

Exclamation mark

警示用语:

Warning

危险分类

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3

靶器官

Respiratory system

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable


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