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Merck
CN

415480

氯喹 二磷酸盐

97%

别名:

N4-(7-氯-4-喹啉基)-N1,N1-二甲基-1,4-戊二胺 二磷酸盐

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经验公式(希尔记法):
C18H26ClN3 · 2H3PO4
化学文摘社编号:
分子量:
515.86
EC Number:
200-055-2
UNSPSC Code:
12352100
MDL number:
Beilstein/REAXYS Number:
4223142
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产品名称

氯喹 二磷酸盐, 97%

InChI

1S/C18H26ClN3.2H3O4P/c1-4-22(5-2)12-6-7-14(3)21-17-10-11-20-18-13-15(19)8-9-16(17)18;2*1-5(2,3)4/h8-11,13-14H,4-7,12H2,1-3H3,(H,20,21);2*(H3,1,2,3,4)

InChI key

QKICWELGRMTQCR-UHFFFAOYSA-N

SMILES string

OP(O)(O)=O.OP(O)(O)=O.CCN(CC)CCCC(C)Nc1ccnc2cc(Cl)ccc12

assay

97%

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David J Bacon et al.
Antimicrobial agents and chemotherapy, 51(4), 1172-1178 (2007-01-16)
In vitro drug susceptibility testing with the malaria parasite has been used to assess the antimalarial activities of new compounds and to monitor drug resistance in field isolates. We investigated the validity of a SYBR green I fluorescent-based assay under
Gajanan Wanare et al.
Bioorganic & medicinal chemistry letters, 20(15), 4675-4678 (2010-06-26)
Both the lack of a credible malaria vaccine and the emergence and spread of parasites resistant to most of the clinically used antimalarial drugs and drug combination have aroused an imperative need to develop new drugs against malaria. In present
Changkun Hu et al.
European journal of medicinal chemistry, 45(2), 705-709 (2009-12-01)
The purpose of this study was to evaluate the enhancement value of chloroquine analogs when used in combination with Akt inhibitors on the MDA-MB468, MDA-MB231 and MCF7 human breast cancer cell lines. The result showed that the combination of certain
Margaret A L Blackie et al.
Bioorganic & medicinal chemistry letters, 20(3), 1078-1080 (2009-12-26)
Synthesis of the potent antiplasmodial 4-aminoquinoline, phenylequine (PQ), is reported for the first time. PQ and the two analogues show increased efficacy in moving from the chloroquine sensitive D10 to the chloroquine resistant K1 strain in vitro. The in vivo
Onyeka Onyeibor et al.
Journal of medicinal chemistry, 48(7), 2701-2709 (2005-04-02)
A series of analogues of cryptolepine (1) have been synthesized and evaluated for their in vitro antiplasmodial and cytotoxic properties. The IC(50) values of several compounds (11a, 11k-m, 11o, 13) against Plasmodium falciparum (strain K1) were <0.1 muM, 5-10-fold lower

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