399027
马钱子碱
anhydrous, 98%
别名:
10,11-二甲氧基马钱子碱
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关于此项目
经验公式（希尔记法）:
C23H26N2O4
化学文摘社编号:
分子量:
394.46
UNSPSC Code:
12352210
NACRES:
NA.22
PubChem Substance ID:
EC Number:
206-614-7
Beilstein/REAXYS Number:
63046
MDL number:
Assay:
98%
InChI key
RRKTZKIUPZVBMF-IBTVXLQLSA-N
InChI
1S/C23H26N2O4/c1-27-16-8-14-15(9-17(16)28-2)25-20(26)10-18-21-13-7-19-23(14,22(21)25)4-5-24(19)11-12(13)3-6-29-18/h3,8-9,13,18-19,21-22H,4-7,10-11H2,1-2H3/t13-,18-,19-,21-,22-,23+/m0/s1
SMILES string
[H][C@@]12CC(=O)N3c4cc(OC)c(OC)cc4[C@]56CC[N@H]7CC(=CCO1)[C@]([H])(C[C@@H]57)[C@]2([H])[C@]36[H]
grade
anhydrous
assay
98%
optical activity
[α]20/D −118°, c = 2.5 in chloroform
mp
175-178 °C (dec.) (lit.)
functional group
ether
Quality Level
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General description
Brucine is the major active pharmacological component of Strychnos nux-vomica seeds, which is known for its anti-inflammatory and analgesic activities.
Application
Brucine may be used as chiral resolving agent for the optical resolution of tertiary acetylenic alcohols into enantiomers.
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 1 Oral - Acute Tox. 2 Inhalation - Aquatic Chronic 3
存储类别
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
法规信息
监管及禁止进口产品
此项目有
Jun Chen et al.
Fitoterapia, 82(8), 1302-1308 (2011-10-01)
The toxicity depending on both dose and administration route is the major obstacle to the development of brucine, a bioactive alkaloid from Semen Strychni. In this study, the apparent partition coefficient and plasma protein binding extent of brucine were determined.
A new optical resolution method of tertiary acetylenic alcohol utilizing complexation with brucine.
Toda F, et al.
Tetrahedron Letters, 22(46), 4669-4672 (1981)
Ping Li et al.
Chinese journal of integrative medicine, 18(8), 605-609 (2012-08-03)
To study the effects of brucine on vascular endothelial growth factor (VEGF) expression and microvessel density (MVD) in a nude mouse model of bone metastasis due to breast cancer, and to assess the possible antitumor mechanism of brucine. A syringe
Jian-Min Qin et al.
International journal of nanomedicine, 7, 369-379 (2012-02-16)
Hepatocellular carcinoma is difficult to diagnose early, and most patients are already in the late stages of the disease when they are admitted to hospital. The total 5-year survival rate is less than 5%. Recent studies have showed that brucine
Xueguo Chen et al.
Journal of analytical toxicology, 36(3), 171-176 (2012-03-16)
A liquid chromatography-electrospray ionization-ion trap mass spectrometry (LC-ESI-ITMS) method was developed for the simultaneous analysis of strychnine, brucine and their major metabolites. Strychnine and brucine were individually incubated with rat liver S9 fraction. The incubation samples were pooled together and
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