399027
马钱子碱
anhydrous, 98%
别名:
10,11-二甲氧基马钱子碱
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关于此项目
经验公式（希尔记法）:
C23H26N2O4
化学文摘社编号:
分子量:
394.46
UNSPSC Code:
12352210
NACRES:
NA.22
PubChem Substance ID:
EC Number:
206-614-7
Beilstein/REAXYS Number:
63046
MDL number:
产品名称
马钱子碱, anhydrous, 98%
InChI key
RRKTZKIUPZVBMF-IBTVXLQLSA-N
InChI
1S/C23H26N2O4/c1-27-16-8-14-15(9-17(16)28-2)25-20(26)10-18-21-13-7-19-23(14,22(21)25)4-5-24(19)11-12(13)3-6-29-18/h3,8-9,13,18-19,21-22H,4-7,10-11H2,1-2H3/t13-,18-,19-,21-,22-,23+/m0/s1
SMILES string
[H][C@@]12CC(=O)N3c4cc(OC)c(OC)cc4[C@]56CC[N@H]7CC(=CCO1)[C@]([H])(C[C@@H]57)[C@]2([H])[C@]36[H]
grade
anhydrous
assay
98%
optical activity
[α]20/D −118°, c = 2.5 in chloroform
mp
175-178 °C (dec.) (lit.)
functional group
ether
Quality Level
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General description
Brucine is the major active pharmacological component of Strychnos nux-vomica seeds, which is known for its anti-inflammatory and analgesic activities.
Application
Brucine may be used as chiral resolving agent for the optical resolution of tertiary acetylenic alcohols into enantiomers.
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 1 Oral - Acute Tox. 2 Inhalation - Aquatic Chronic 3
存储类别
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
法规信息
监管及禁止进口产品
此项目有
A Novel Brucine Gel Transdermal Delivery System Designed for Anti-Inflammatory and Analgesic Activities.
Wu P, et al.
International Journal of Molecular Medicine, 18(4), 757-757 (2017)
Jun Chen et al.
Fitoterapia, 82(8), 1302-1308 (2011-10-01)
The toxicity depending on both dose and administration route is the major obstacle to the development of brucine, a bioactive alkaloid from Semen Strychni. In this study, the apparent partition coefficient and plasma protein binding extent of brucine were determined.
S S Agrawal et al.
Life sciences, 89(5-6), 147-158 (2011-06-21)
Brucine (BRU), a natural plant alkaloid is reported to possess cytotoxic and antiproliferative activities. In this study we aimed to investigate its in vitro and in vivo antitumor and antiangiogenic effects. Cell proliferation and viability was assessed using microculture tetrazolium
Mohsen Behpour et al.
Phytochemical analysis : PCA, 23(2), 95-102 (2011-05-28)
Strychnos nux-vomica L. (Loganiaceae), widely used in folk medicine, is grown extensively in southern Asian countries. Its major bioactive constituents are strychnine and brucine, which are frequently used in traditional herbal medicines for treatment of nervous diseases, vomiting and traumatic
Hong-Mei Zhang et al.
Molecular biology reports, 39(4), 4937-4947 (2011-12-14)
The features of brucine (BC) binding to two blood proteins, bovine hemoglobin (BHb), and bovine serum albumin (BSA), were investigated via fluorescence, circular dichroism and UV/Vis absorption spectroscopy. The results revealed that BC caused the fluorescence quenching of blood proteins
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