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Merck
CN
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文件

396494

Sigma-Aldrich

氨基胍 盐酸盐

≥98%

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别名:
甲脒肼 盐酸盐
线性分子式:
NH2NHC(=NH)NH2 · HCl
CAS号:
1937-19-5
分子量:
110.55
Beilstein:
3909606
EC 号:
217-707-7
MDL编号:
MFCD00039074
UNSPSC代码:
12352100
PubChem化学物质编号:
24864672
NACRES:
NA.22

质量水平

200

检测方案

≥98%

形式

solid

mp

162-166 °C (lit.)

SMILES字符串

Cl.NNC(N)=N

InChI

1S/CH6N4.ClH/c2-1(3)5-4;/h4H2,(H4,2,3,5);1H

InChI key

UBDZFAGVPPMTIT-UHFFFAOYSA-N

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相关类别

一般描述

在一项研究中已经报道了氨基胍盐酸盐可作为动物一氧化氮（NO）-合酶的抑制剂。已采用傅立叶和最小二乘法对盐酸氨基胍的晶体结构进行了研究。其晶体为单斜晶体，氨基胍离子的胍部分是平面结构。

应用

氨基胍盐酸盐可作为一氧化氮合酶（NOS）的抑制剂，用于研究其对大鼠结扎性牙周炎牙槽骨损失的影响。它可用于合成5-脒腙衍生物，其具有抗 大肠杆菌 和 金黄色葡萄球菌的抗菌活性。

生化/生理作用

构成型和诱导型一氧化氮合酶两者都抑制。

象形图

Exclamation markEnvironment
GHS07,GHS09

警示用语：

Warning

危险声明

H317,H411

危险分类

Aquatic Chronic 2 - Skin Sens. 1B

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves

分析证书(COA)

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  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  2. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  3. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  4. Is there another aminoguanidine product suitable for cell culture?

    Aminoguanidine hemisulfate salt, Product No. A7009, is water soluble, so it may be worth trying. But we do not offer an aminoguanidine product that has been cell culture tested by Sigma-Aldrich.

  5. What impurities might be present in Product 396494, Aminoguanidine hydrochloride?

    Malononitrile and urea might be present in minute amounts.

  6. At what temperature should Product 396494, Aminoguanidine hydrochloride, be stored?

    The material should be stored at room temperature.

  7. What solvent can Product 396494, Aminoguanidine hydrochloride, be dissolved in?

    This product is soluble in water at 50 mg/mL, yielding a clear, colorless to faint yellow solution. Heat may be required to get the material to dissolve at that concentration.

  8. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  9. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

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The level of nitric oxide (NO) in roots of 2-day-old etiolated pea (Pisum sativum L.) seedlings was investigated by fluorescence microscopy using the fluorescent probe 4,5-diaminofluorescein diacetate. Segments representing transversal (cross) cuts of the roots having thickness of 100 to
A K Gadad et al.
European journal of medicinal chemistry, 35(9), 853-857 (2000-09-28)
6-Arylimidazo[2,1-b]-1,3,4-thiadiazole-2-sulfonamides 3 on Vilsmeier-Haak reaction produced 5-formyl-6-arylimidazo[2,1-b]-1,3, 4-thiadiazole-2-[N-(dimethylaminomethino)]sulfonamides 4, while 3 on treatment with potassium thiocyanate in the presence of bromine in acetic acid produced 5-thiocyanato-2-sulfonamides 6. Interaction of 4 with aminoguanidine hydrochloride in ethanol produced the corresponding 5-guanylhydrazone derivatives
Manju Gurung et al.
Bioresource technology, 129, 108-117 (2012-12-15)
A new adsorption gel has been developed by immobilizing N-aminoguanidine (AG), a chelating ligand, on persimmon tannin extract through consecutive reactions. Adsorption behavior of the gel was investigated for the adsorptive separation and recovery of precious metal ions from varying
Ivaylo P Ivanov et al.
Molecular cell, 70(2), 254-264 (2018-04-21)
Translation initiation is typically restricted to AUG codons, and scanning eukaryotic ribosomes inefficiently recognize near-cognate codons. We show that queuing of scanning ribosomes behind a paused elongating ribosome promotes initiation at upstream weak start sites. Ribosomal profiling reveals polyamine-dependent pausing
Lina Nordquist et al.
Advances in experimental medicine and biology, 765, 185-193 (2012-08-11)
Sustained hyperglycemia is closely associated with increased risk to develop nephropathy. We have previously reported alterations in the intrarenal oxygen metabolism already after the early onset of diabetes. Furthermore, formation of advanced glycation end-products (AGE) is postulated as a major
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