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检测方案
98%
形式
solid
bp
167-168 °C/23 mmHg (lit.)
mp
39-41 °C (lit.)
密度
1.065 g/mL at 25 °C (lit.)
SMILES字符串
CC(Cc1ccccc1)C(O)=O
InChI
1S/C10H12O2/c1-8(10(11)12)7-9-5-3-2-4-6-9/h2-6,8H,7H2,1H3,(H,11,12)
InChI key
MCIIDRLDHRQKPH-UHFFFAOYSA-N
一般描述
α-Methylhydrocinnamic acid (2-methyl-3-phenylpropionic acid, 2-benzylpropionic acid) is a cinnamic acid derivative. Its synthesis by the asymmetric hydrogenation of α-methylcinnamic acid has been reported. α-Methylhydrocinnamic acid, a short chain fatty acid derivative (SCFAD), has been reported to correct the cystic fibrosis transmembrane conductance regulator (ΔF508-CFTR) defect. Conformational studies of 2-methyl-3-phenylpropionic acid has been investigated by NMR spectroscopy. The enantiomers of 2-benzylpropionic acid has been reported to be synthesized using a lipase-catalyzed resolution. (S) (+)-2-methyl-3-phenylpropionic acid participates in the synthesis of optically active (R)-5-methyl-6-phenylhexanoyl azide. L-2-Methyl-3.phenylpropionic acid has been reported to be an inhibitor of carboxypeptidase A. Polymer-supported “Evans” oxazolidinone mediated solid phase asymmetric has been employed in the synthesis of (S)-2-methyl-3-phenylpropionic acid.
应用
α-Methylhydrocinnamic acid is suitable for use in the comparative study to investigate the γ-globin inducibility of short-chain fatty acid derivatives (SCFADs) in mice. It may be used as a histone deacetylase (HDAC) inhibitor in the comparative study to investigate the EGFP-induction potency of a number of HDAC inhibitors. It may be used in the study to investigate the selectivity of the sensor based on imprinted poly(o-phenylenediamine) (iPoPD).
警示用语:
Warning
危险声明
危险分类
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
WGK
WGK 3
闪点(°F)
closed cup
闪点(°C)
closed cup
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
Stereochemical Studies. V. Intramolecular CH Bond Insertion Reaction of Acyl Nitrene generated from optically Active Acyl Azide.
Chemical & Pharmaceutical Bulletin, 18(6), 1124-1136 (1970)
Conformational studies of 2-methyl-3-phenylpropionic acid, 2-phenylbutyric acid and their methyl esters by NMR spectroscopy.
Journal of Molecular Structure, 53, 219-224 (1979)
A potent reversible inhibitor of carboxypeptidase A.
The Journal of biological chemistry, 247(2), 606-608 (1972-01-25)
The preparation and first application of a polymer-supported ?Evans? oxazolidinone.
Tetrahedron Letters, 37(44), 8023-8026 (1996)
Journal of hazardous materials, 192(3), 1633-1640 (2011-07-29)
Microbial degradation of the chiral 2-phenylbutyric acid (2-PBA), a metabolite of surfactant linear alkylbenzene sulfonates (LAS), was investigated using both racemic and enantiomer-pure compounds together with quantitative stereoselective analyses. A pure culture of bacteria, identified as Xanthobacter flavus strain PA1
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