推荐产品
应用
作为反应物用于制备：
- 作为甲流病毒M2质子通道有效抑制剂和结构探针的有机硅烷胺
- 作为拓扑异构酶I抑制剂以及潜在抗肿瘤剂的Lamellarin D类似物
- 作为用于预防早产的前列腺素F2α受体抑制剂的Azapeptide宫缩抑制剂
- 与吲哚啉-2-酮螺旋稠合的噻唑烷酮，作为结核分枝杆菌蛋白酪氨酸磷酸酶B的有效且选择性抑制剂
- 口服生物可利用的靶向Lys554基于喹啉的抗糖尿病二肽基肽酶IV抑制剂
- 与一氧化氮供体作为抗病毒剂的嘧啶核苷衍生物
- 靶向腺苷A2A受体和腺苷转运蛋白用于神经保护的苄基腺苷化合物
- 作为香草素受体TRPV1的抑制剂并在尿失禁的大鼠膀胱测压模型中具有改善潜力的萘酚衍生物
生化/生理作用
MAO 抑制剂;抑制血小板聚集。
警示用语：
Warning
危险分类
Acute Tox. 4 Dermal - Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 2 - Carc. 2 - Eye Irrit. 2 - Met. Corr. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT RE 2 Oral
靶器官
spleen
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
Ken Berglund et al.
Journal of neuroscience research, 98(3), 422-436 (2019-04-09)
Although molecular tools for controlling neuronal activity by light have vastly expanded, there are still unmet needs which require development and refinement. For example, light delivery into the brain is still a major practical challenge that hinders potential translation of
Hironobu Maezaki et al.
Bioorganic & medicinal chemistry, 19(15), 4482-4498 (2011-07-12)
Dipeptidyl peptidase IV (DPP-4) inhibition is a validated therapeutic option for type 2 diabetes, exhibiting multiple antidiabetic effects with little or no risk of hypoglycemia. In our studies involving non-covalent DPP-4 inhibitors, a novel series of quinoline-based inhibitors were designed
Shi, J.; et al.
Chinese Chemical Letters = Zhongguo Hua Xue Kuai Bao, 22, 899-899 (2011)
Salvatore Cananzi et al.
Bioorganic & medicinal chemistry, 19(16), 4971-4984 (2011-07-26)
A novel 5-oxa-6a,8-diazaindeno[2,1-b]phenanthren-7-one scaffold was designed and synthesized as an active analogue of the cytotoxic marine alkaloid Lamellarin D. The design was based on molecular modeling of the site of interaction of Lamellarin D with DNA-topoisomerase I cleavable complex, whereas
Klaus Urbahns et al.
Bioorganic & medicinal chemistry letters, 21(11), 3354-3357 (2011-05-03)
We have identified naphthol derivatives as inhibitors of the vanilloid receptor TRPV1 by high throughput screening. The initial lead showed high clearance in rats and has been optimized by enhancing the acidity of the phenol group. Compound 6b has reduced
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