37580
3,4-二羟基苯甲酸
≥97.0% (T)
别名:
原儿茶酸
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关于此项目
线性分子式:
(HO)2C6H3CO2H
化学文摘社编号:
分子量:
154.12
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
EC Number:
202-760-0
Beilstein/REAXYS Number:
1448841
MDL number:
产品名称
3,4-二羟基苯甲酸, ≥97.0% (T)
InChI key
YQUVCSBJEUQKSH-UHFFFAOYSA-N
InChI
1S/C7H6O4/c8-5-2-1-4(7(10)11)3-6(5)9/h1-3,8-9H,(H,10,11)
SMILES string
OC(=O)c1ccc(O)c(O)c1
assay
≥97.0% (T)
mp
197-200 °C (dec.) (lit.)
functional group
carboxylic acid
Quality Level
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Application
3,4-二羟基苯甲酸适用于在体内研究4-香豆酸和3,4-二羟基苯甲酸对大鼠结肠黏膜基础氧化性DNA损伤的影响。它可用于壳聚糖树脂的衍生化。
Biochem/physiol Actions
几个致癌作用的动物模型中的化学防癌剂。在后启动阶段阻断细胞增殖。
General description
据报道，3,4-二羟基苯甲酸是一种食品多酚。在小鼠模型中，3,4-二羟基苯甲酸（原儿茶酸，PCA）对毒性H9N2病毒株的抗病毒活性已有报道。PCA对3种非小细胞肺癌（NSCLC）细胞系（A549、H3255和Calu-6细胞系）的细胞毒性作用已有报道。据报道，PCA可在体内预防癌变或抗肿瘤生长。PCA诱导的人胃腺癌（AGS）细胞凋亡的相关信号通路已有报道。水/针铁矿料浆中的H2O2在不同操作条件（催化剂负载、温度、酸碱度、底物和过氧化氢起始浓度）下，对3，4-二羟苯甲酸的氧化作用已有研究。
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Akhmad Sabarudin et al.
Analytica chimica acta, 581(2), 214-220 (2007-03-28)
A chitosan resin derivatized with 3,4-dihydroxybenzoic acid moiety (CCTS-DHBA resin) was newly synthesized for the collection/concentration of trace uranium by using cross-linked chitosan (CCTS) as base material, and the adsorption behavior of uranium as well as 60 elements on the
Hui-Hsuan Lin et al.
International journal of cancer, 120(11), 2306-2316 (2007-02-17)
3,4-Dihydroxybenzoic acid (protocatechuic acid, PCA) is discussed to represent antioxidative food components in a human diet rich in fruits and vegetables, and has been shown to prevent carcinogenesis or antitumor growth in vivo. However, the molecular mechanisms involved in chemopreventive
Francesco Guglielmi et al.
The British journal of nutrition, 89(5), 581-587 (2003-05-02)
The effect of 4-coumaric and 3,4-dihydroxybenzoic (protocatechuic) acid on the basal oxidative DNA damage of rat colonic mucosa in vivo was studied, relative to vitamin E. F344 rats were treated with 4-coumaric or protocatechuic acid mixed in the diet (25
Shih-ming Tsao et al.
Nutrition and cancer, 66(8), 1331-1341 (2014-10-31)
Cytotoxic effects of protocatechuic acid (PCA) upon 3 nonsmall cell lung cancer (NSCLC) cell lines, A549, H3255, and Calu-6 cell lines, were examined. PCA at 1, 2, 4, and 8 μM was used to treat these cells. Results showed that
Roberto Andreozzi et al.
Water research, 36(11), 2761-2768 (2002-07-31)
The oxidation by H2O2 of 3,4-dihydroxybenzoic acid (3,4-DHB) in aqueous/goethite slurry at varying operating conditions (catalyst load, temperature, pH, substrate and hydrogen peroxide starting concentration) is investigated. At adopted catalyst loads the observed kinetic developments are consistent with a non-radicalic
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