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主要文件

375217

Sigma-Aldrich

2-氯-4,6-二甲氧基-1,3,5-三嗪

97%

别名:

2,4-二甲氧基-6-氯-1,3,5-三嗪, 2,4-二甲氧基-6-氯-s-三嗪, 2-氯-4,6-二甲氧基-1,3,5-三嗪, 2-氯-4,6-二甲氧基-s-三嗪, 4,6-二甲氧基-2-氯-s-三嗪, 6-氯-2,4-二甲氧基-s-三嗪, CDMT, 氯二甲氧基三嗪

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1500 UNITS
¥2,835.93
3000 UNITS
¥6,490.88
7500 UNITS
¥12,980.62

About This Item

经验公式(希尔记法):
C5H6ClN3O2
CAS号:
分子量:
175.57
Beilstein:
148988
EC 号:
MDL编号:
UNSPSC代码:
12352100
PubChem化学物质编号:
NACRES:
NA.22

¥2,835.93

目录价¥3,781.24节省 25%

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质量水平

方案

97%

表单

solid

mp

71-74 °C (lit.)

官能团

chloro

SMILES字符串

COc1nc(Cl)nc(OC)n1

InChI

1S/C5H6ClN3O2/c1-10-4-7-3(6)8-5(9-4)11-2/h1-2H3

InChI key

GPIQOFWTZXXOOV-UHFFFAOYSA-N

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一般描述

2-氯-4,6-二甲氧基-1,3,5-三嗪是一种稳定但高度活性的肽偶联剂。[1]它被报道为多肽纯化的有效偶联试剂。[2]已报道 2-氯-4,6-二甲氧基-1,3,5-三嗪的催化酰胺化反应。[3]已报道制备多千克 2-氯-4,6-二甲氧基-1,3,5-三嗪的方法。[4]

应用

2-氯-4,6-二甲氧基-1,3,5-三嗪可用于以下研究:
  • 亲和标记的模块化方法 (MoAL) 对链霉亲和素的特异性标记。[5]
  • 通过与 2-羟基-4,6-二甲氧基-1,3,5-三嗪-2-基)醚反应制备双(4,6-二甲氧基-1,3,5-三嗪-2-基)醚。[6]
  • 通过与多种叔胺反应制备 2-(4,6-二甲氧基-1,3,5-三嗪基)三烷基铵盐。[7]
  • 在四氢呋喃中与 N -甲基吗啉偶联合成 4-(4,6-二甲氧基-1,3,5-三嗪-2-基)-4-甲基吗啉氯化物。[8]
一种稳定并且具高反应性的肽偶联剂。[1]

警示用语:

Danger

危险声明

危险分类

Aquatic Chronic 2 - Eye Dam. 1 - Skin Corr. 1B - Skin Sens. 1

储存分类代码

8A - Combustible corrosive hazardous materials

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves

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  • 历史批次信息供参考:

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    2-Chloro-4, 6-dimethoxy-1, 3, 5-triazine. A new coupling reagent for peptide synthesis.
    Kaminski ZJ.
    Synthesis, 10, 917-920 (1987)
    An improved procedure for the large scale preparation of 2-chloro-4, 6-dimethoxy-1, 3, 5-triazine.
    Cronin JS, et al.
    Synthetic Communications, 26(!8), 3491-3494 (1996)
    Synthesis, 917-917 (1987)
    E Johanna L Stéen et al.
    ACS nano, 14(1), 568-584 (2019-12-11)
    Tumor targeting using agents with slow pharmacokinetics represents a major challenge in nuclear imaging and targeted radionuclide therapy as they most often result in low imaging contrast and high radiation dose to healthy tissue. To address this challenge, we developed
    Konrad Jastrzabek et al.
    Chemistry & biodiversity, 10(5), 952-961 (2013-05-18)
    Bis(4,6-dimethoxy-1,3,5-triazin-2-yl) ether (4) was prepared by treatment of 2-hydroxy-4,6-dimethoxy-1,3,5-triazine with 2-chloro-4,6-dimethoxy-1,3,5-triazine in 61% yield. Ether 4, isoelectronic with pyrocarbonates, was found capable to activate carboxylic acids in the presence of 1,4-diazabicyclo[2.2.2]octane (DABCO) to yield, under mild reaction conditions, superactive triazine

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