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同位素纯度
98 atom % 13C
质量水平
方案
99% (CP)
表单
white powder
mp
>300 °C (lit.)
质量偏移
M+1
储存温度
room temp
SMILES字符串
[Na].O[13C](O)=O
InChI
1S/CH2O3.Na/c2-1(3)4;/h(H2,2,3,4);/q;+1/p-1/i1+1;
InChI key
UIIMBOGNXHQVGW-YTBWXGASSA-M
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一般描述
碳酸氢钠-13C 是碳酸氢钠的同位素富集化合物。
应用
碳酸氢钠-13C 用于通过超极化13C pH 成像和多参数 MRI研究乳酸代谢。该试剂可用作核磁共振波谱法研究中的探针， 从而在低毒性超极化13C pH成像中使鼠前列腺模型的体模和体内获得大信号增益。
碳酸氢钠-13C可用于：
- 作为基于NMR−和MRI−的pH成像的探针。
- 预测钌(III)铬合物催化的碳酸氢盐选择性加氢生成甲酸盐的反应机理。
- 用于氨基酸样品13C标记特定化合物稳定同位素分析(CSIA)。
包装
这种产品可以大量现货供应，也可以按需包装。有关定价、供货和包装的信息，请联系稳定同位素客户服务。
储存分类代码
13 - Non Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
D E Korenchan et al.
Chemical communications (Cambridge, England), 52(14), 3030-3033 (2016-01-23)
A hyperpolarization technique using carbonate precursors of biocompatible molecules was found to yield high concentrations of hyperpolarized (13)C bicarbonate in solution. This approach enabled large signal gains for low-toxicity hyperpolarized (13)C pH imaging in a phantom and in vivo in
Current concepts on hyperpolarized molecules in MRI.
Viale A and Aime S
Current Opinion in Chemical Biology, 14(1), 90-96 (2010)
Quantified pH imaging with hyperpolarized 13 C-bicarbonate
Scholz DJ, et al.
Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine, 73(6), 2274-2282 (2015)
Ferdia A Gallagher et al.
NMR in biomedicine, 24(8), 1006-1015 (2011-08-04)
pH is a fundamental physiological parameter that is tightly controlled by endogenous buffers. The acid-base balance is altered in many disease states, such as inflammation, ischemia and cancer. Despite the importance of pH, there are currently no routine methods for
David E Korenchan et al.
Oncotarget, 10(58), 6096-6110 (2019-11-07)
There is an unmet clinical need for new and robust imaging biomarkers to distinguish indolent from aggressive prostate cancer. Hallmarks of aggressive tumors such as a decrease in extracellular pH (pHe) can potentially be used to identify aggressive phenotypes. In
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