所有图片(1)
About This Item
经验公式（希尔记法）:
C16H10O
CAS号:
分子量:
218.25
MDL编号:
UNSPSC代码:
12352100
PubChem化学物质编号:
NACRES:
NA.22
推荐产品
质量水平
方案
98%
mp
179-182 °C (lit.)
SMILES字符串
Oc1ccc2ccc3cccc4ccc1c2c34
InChI
1S/C16H10O/c17-14-9-7-12-5-4-10-2-1-3-11-6-8-13(14)16(12)15(10)11/h1-9,17H
InChI key
BIJNHUAPTJVVNQ-UHFFFAOYSA-N
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一般描述
1-羟基芘作为尿液代谢产物，是多环芳烃 (PAH) 暴露的标志物。1-羟基芘是暴露于芘的重要生物标志物。
应用
1-羟基芘适用于以下研究：
- 探讨用简单的荧光法快速检测和定量测定暴露于沉积物相关芘的杂色沙蚕组织提取液中的 1-羟基芘。
- 探讨细胞色素 P450 1A1 (CYP1A1) 和 2E1 (CYP2E1) 以及谷胱甘肽 S-转移酶 mu (GSTM1) 和 θ (GSTT1) 的基因多态性对飞机维修工人尿 1-羟基芘和 2-萘酚水平的影响。
- 研究爱沙尼亚油页岩加工厂焦化厂工人的多环芳烃暴露情况。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
Zheng Li et al.
Chemical research in toxicology, 25(7), 1452-1461 (2012-06-06)
Human exposure to polycyclic aromatic hydrocarbons (PAHs) can be assessed by biomonitoring of their urinary monohydroxylated metabolites (OH-PAHs). Limited information exists on the human pharmacokinetics of OH-PAHs. This study aimed to investigate the excretion half-life of 1-hydroxypyrene (1-PYR), the most
T Kuljukka et al.
Environmental health perspectives, 104 Suppl 3, 539-541 (1996-05-01)
The exposure of Estonian cokery workers to polynuclear aromatic hydrocarbons at an oil shale processing plant was assessed by occupational hygiene and biomonitoring measurements. To assess the external dose of exposure to polynuclear aromatic hydrocarbons, pyrene and benzo[a]pyrene concentrations were
P Strickland et al.
Toxicology letters, 108(2-3), 191-199 (1999-10-08)
Humans are exposed to polycyclic aromatic hydrocarbons (PAHs) from occupational, environmental, medicinal and dietary sources. PAH metabolites in human urine can be used as biomarkers of internal dose to assess recent exposure to PAHs. The most widely used urinary PAH
Thomas W Fuller et al.
Scientific reports, 8(1), 507-507 (2018-01-13)
Electronic cigarette (EC) use is gaining popularity as a substitute for conventional smoking due to the perception and evidence it represents a safer alternative. In contrast to the common perception amongst users that ECs represent no risk initial studies have
Tsutomu Shimada et al.
Xenobiotica; the fate of foreign compounds in biological systems, 48(6), 565-575 (2017-06-27)
1. 1-Chloropyrene, one of the major chlorinated polycyclic aromatic hydrocarbon contaminants, was incubated with human cytochrome P450 (P450 or CYP) enzymes including CYP1A1, 1A2, 1B1, 2A6, 2A13, 2B6, 2C9, 2D6, 2E1, 3A4 and 3A5. Catalytic differences in 1-chloropyrene oxidation by polymorphic
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