所有图片(1)
About This Item
线性分子式:
HO2C(CH2)3P(C6H5)3Br
CAS号:
分子量:
429.29
MDL编号:
UNSPSC代码:
12352002
PubChem化学物质编号:
NACRES:
NA.22
质量水平
检测方案
98%
反应适用性
reaction type: C-C Bond Formation
mp
244-247 °C (lit.)
SMILES字符串
[Br-].OC(=O)CCC[P+](c1ccccc1)(c2ccccc2)c3ccccc3
InChI
1S/C22H21O2P.BrH/c23-22(24)17-10-18-25(19-11-4-1-5-12-19,20-13-6-2-7-14-20)21-15-8-3-9-16-21;/h1-9,11-16H,10,17-18H2;1H
InChI key
NKVJKVMGJABKHV-UHFFFAOYSA-N
应用
用作制备以下物质的反应物：
- 哌啶类似物，作为具有抗肿瘤活性的组蛋白脱乙酰基酶（HDAC）抑制剂
- 含硼的苯并氧杂硼烷类化合物，作为抗疟药
- 甲基烯基喹诺酮类化合物，作为抗分枝杆菌剂
- 依次经过Sharpless环氧化反应、Taber环丙烷化反应、化学选择性还原反应和锂化-硼化-烯丙基化反应，合成Solandelactone E
- 有机锡化合物，作为抗真菌剂
- 齐墩果酸衍生物作为蛋白酪氨酸磷酸酶1B的抑制剂，可抑制胰岛素途径（糖尿病和肥胖症治疗的有前景的靶标）
- 11-oxa前列腺素类似物，具有降眼压活性
警示用语：
Warning
危险声明
危险分类
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
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