推荐产品
检测方案
97%
mp
138-140 °C (lit.)
SMILES字符串
O=C1N(c2ccccc2)c3ccccc3C1=O
InChI
1S/C14H9NO2/c16-13-11-8-4-5-9-12(11)15(14(13)17)10-6-2-1-3-7-10/h1-9H
InChI key
UWCPWBIMRYXUOU-UHFFFAOYSA-N
一般描述
1-Phenylisatin is an isatin. It is a potential anticancer, anti-HIV drug. Its binding interaction with a model transport protein bovine serum albumin (BSA) has been investigated using fluorescence spectroscopic technique. Interactions between human adult hemoglobin (Hb) and 1-phenylisatin has been investigated by steady state and time-resolved fluorescence along with circular dichroism (CD) spectroscopic, FTIR and anisotropy.
应用
Reactant for preparation of:
- Indolin-2,3-dione Schiff bases as potential antimycobacterial agents
- Antipyretic agents
- Antiproliferative agents
- Selective Cannabinoid Receptor 2 Agonists for the Treatment of Neuropathic Pain
- Phenylacetamides as anticonvulsant agents
- Selective Galanin GAL3 Receptor Antagonists
警示用语：
Warning
危险声明
预防措施声明
危险分类
Acute Tox. 4 Oral
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
法规信息
新产品
Bijan Kumar Paul et al.
Physical chemistry chemical physics : PCCP, 15(4), 1275-1287 (2012-12-13)
The present contribution reports a detailed characterization of the binding interaction of a potential anticancer, anti-HIV drug 1-phenylisatin (1-PI) with a model transport protein Bovine Serum Albumin (BSA) using fluorescence spectroscopic techniques. The thermodynamic parameters e.g., ΔH, ΔS and ΔG
Puspita Sahu et al.
Psychopharmacology, 236(6), 1829-1838 (2019-01-23)
Cannabinoid receptor 2 (CB2R) signaling in the brain is associated with the pathophysiology of depression. Sickness behavior, characterized by lessened mobility, social interaction, and depressive behavior, is linked with neuroinflammation, oxidative stress, and immune system. The present study was aimed
Paulami Mandal et al.
The journal of physical chemistry. B, 113(45), 14904-14913 (2009-10-13)
In this report, steady state and time-resolved fluorescence along with circular dichroism (CD) spectroscopic, FTIR, and anisotropy investigations were made to reveal the nature of the interactions between human adult hemoglobin (Hb) and the isatins, 1-methylisatin (1-MI) and 1-phenylisatin (1-PI).
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